The elucidation of physiological functions of transcription factor FoxO1 in pancreatic alpha cell
The elucidation of physiological functions of transcription factor FoxO1 in pancreatic alpha cell
批准号:
23791013
负责人:
KOBAYASHI Masaki
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
To elucidate the physiological roles of FoxO1 in pancreatic alpha cell, we prepared and analyzed the character of alpha cell-specific constitutive active-FoxO1 knockin mice (alpha-FoxO1-KI). Alpha-FoxO1 KI mice showed significant increases in plasma glucagon and blood glucose levels under random fed condition. We conclude that FoxO1 promotes glucagon secretion from pancreatic alpha cell.
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マウス膵α細胞における転写因子FoxO1の生理機能
转录因子FoxO1在小鼠胰腺α细胞中的生理功能
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[宇野健司, 片桐秀樹, 牧(黒田)由紀子, 牧(黒田) 由紀子, 牧(黒田)由紀子, 小林雅樹菊池司李容守佐々木努北村忠弘]
通讯作者:
小林雅樹菊池司李容守佐々木努北村忠弘
グルカゴン調節における
転写因子FoxO1 の生理機能
胰高血糖素调节
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[宇野健司, 片桐秀樹, 牧(黒田)由紀子, 牧(黒田) 由紀子, 牧(黒田)由紀子, 小林雅樹菊池司李容守佐々木努北村忠弘, 小林雅樹菊池司李容守北村忠弘, 小林雅樹]
通讯作者:
小林雅樹
転写因子FoxO1 のマウス膵臓における生理機能
小鼠胰腺转录因子FoxO1的生理功能
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[小林雅樹, 菊池司, 橋本博美, 北村忠弘]
通讯作者:
北村忠弘
転写因子FoxO1のマウス膵臓における生理機能
小鼠胰腺转录因子FoxO1的生理功能
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[小林雅樹, 菊池司, 橋本博美, 北村忠弘]
通讯作者:
北村忠弘
群馬大学生体調節研究所代謝シグナル解析分野
群马大学生物调节研究所代谢信号分析系
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
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