Development of sentinel-lymphnode imaging system by ultrasonic tagging fluorescence imaging technique

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Fluorescence imaging technique for detecting sentinel-lymphnodeshas been studied. A prototype of a probe-device using ultrasonic modulation of fluorescence, ‘ultrasonic tagging’, was designed and manufactured. Performance to detect a localized fluorophore located at the depth of 20mm in a biological tissue was achieved. To improve the sensitivity for clinical application, which determines fewer amounts of fluorescent molecules, the method to extract the small component of modulated signal has been developed.