Role of desmosomal proteins in skin cancer formation, progression and metastasis
Role of desmosomal proteins in skin cancer formation, progression and metastasis
批准号:
23791300
负责人:
TEYE Kwesi
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
用免疫组化方法检测了鳞状细胞癌(SCC)和基底细胞癌(BCC)中桥粒蛋白的表达。低分化SCC显示桥粒胶蛋白2和3弱阳性,而高分化SCC和BCC显示强阳性。结果提示,桥粒胶蛋白2和3可能在皮肤癌的复发和转移中起一定作用。SCC和BCC中桥粒芯糖蛋白2和3也呈强阳性。
英文摘要
Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) were investigated immunohistochemically for expression of desmosomal proteins. Poorly-differentiated SCC revealed weak positivity for desmocollin 2 and 3, while well-differentiated SCC and BCC revealed strong positivity for them. These results suggested that desmocollin 2 and 3 might play a role in recurrence and metastasis of skin cancer. SCC and BCC also showedstrong positivity for desmoglein 2 and 3.
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Newly developed IgA ELISAs of eukaryotic recombinant proteins of desmocollins 1-3 are more sensitive and specific than baculoprotein ELISAs
新开发的桥粒胶蛋白 1-3 真核重组蛋白 IgA ELISA 比杆状蛋白 ELISA 更灵敏、更特异
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Teye K, Ishii N, Koga H, Hamada T, Karashima T, Numata S, Ohata C, Furumura, M, Hashimoto T]
通讯作者:
Hashimoto T
Newly developed enzyme-linked immunosorbent assays using eukaryotic recombinant proteins of desmocollins (Dsc) are highly sensitive and revealed Dsc2 and Dsc3 as autoantigens specific for paraneoplastic pemphigus
新开发的使用桥粒胶蛋白 (Dsc) 真核重组蛋白的酶联免疫吸附测定法具有高度敏感性,并显示 Dsc2 和 Dsc3 是副肿瘤性天疱疮特异性的自身抗原
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Norito Ishii, Shunpei Fukuda, Kwesi Teye, Atsunari Tsuchisaka, Takahiro Hamada, Daisuke Tsuruta, Teruki Dainichi, Takashi Hashimoto]
通讯作者:
Takashi Hashimoto
Takashi HashimotoNewly developed enzyme-linked immunosorbent assays using eukaryotic recombinant proteins of desmocollins (Dsc) are highly sensitive and revealed Dsc2 and Dsc3 as autoantigens specific for paraneoplastic pemphigus
Takashi Hashimoto 使用桥粒胶蛋白 (Dsc) 真核重组蛋白新开发的酶联免疫吸附测定法具有高度敏感性,并显示 Dsc2 和 Dsc3 是副肿瘤性天疱疮特异性自身抗原
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Norito Ishii, Shunpei Fukuda, Kwesi Teye, Atsunari Tsuchisaka, Takahiro Hamada, Daisuke Tsuruta, Teruki Dainichi]
通讯作者:
Teruki Dainichi
Concurrence of bullous pemphigoid and herpetiform pemphigus with igg antibodies to desmogleins 1/3 and desmocollins 1-3.
大疱性类天疱疮和疱疹样天疱疮同时伴有桥粒芯蛋白 1/3 和桥粒芯蛋白 1-3 的 igg 抗体。
DOI:
10.1111/bjd.12019
发表时间:
2012
期刊:
Br J Dermatol
影响因子:
--
作者:
[Ohata C, Koga H, Teye K, Ishii N, Hamada T, Dainichi T, Furumura M, Sato M, Sueki H, Hashimoto T.]
通讯作者:
Hashimoto T.
Novel adenosine triphosphate (ATP)-binding cassette, subfamily A, member 12 (ABCA12) mutations associated with congenital ichthyosiform erythroderma. Br
与先天性鱼鳞病样红皮病相关的新型三磷酸腺苷 (ATP) 结合盒、A 亚家族、成员 12 (ABCA12) 突变。
DOI:
10.1111/j.1365-2133.2011.10516.x
发表时间:
2012
期刊:
J Dermatol
影响因子:
3.1
作者:
[Fukuda S, Hamada T, Ishii N, Sakaguchi S, Sakai K, Akiyama M, Shimizu H, Masuda K, Izu K, Teye K, Tsuruta D, Karashima T, Nakama T, Yasumoto S, Hashimoto T.]
通讯作者:
Hashimoto T.
共 7 条
Determination of the functions of specific CD44 proteins in human skin and epidermis and their relation to skin diseases, cancer and autoimmunity
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批准号:16K10137
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2016
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负责人:TEYE Kwesi
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依托单位:
Allelic variation of the human ABO secretor locus (FUT2) in the world wide populations
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批准号:14570399
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2002
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负责人:TEYE Kwesi
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依托单位:
海外基金