Role of desmosomal proteins in skin cancer formation, progression and metastasis

桥粒蛋白在皮肤癌形成、进展和转移中的作用

• 批准号: 23791300
• 负责人: TEYE Kwesi
• 金额: $ 2.66万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791300/
• 关键词: 皮膚腫瘍学; 基底細胞癌; 有棘細胞癌; 悪性黒色腫; デスモゾーム; デスモグレイン; デスモコリン; 皮膚癌治療

Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) were investigated immunohistochemically for expression of desmosomal proteins. Poorly-differentiated SCC revealed weak positivity for desmocollin 2 and 3, while well-differentiated SCC and BCC revealed strong positivity for them. These results suggested that desmocollin 2 and 3 might play a role in recurrence and metastasis of skin cancer. SCC and BCC also showedstrong positivity for desmoglein 2 and 3.

用免疫组化方法检测了鳞状细胞癌（SCC）和基底细胞癌（BCC）中桥粒蛋白的表达。低分化SCC显示桥粒胶蛋白2和3弱阳性，而高分化SCC和BCC显示强阳性。结果提示，桥粒胶蛋白2和3可能在皮肤癌的复发和转移中起一定作用。SCC和BCC中桥粒芯糖蛋白2和3也呈强阳性。

项目成果

Newly developed IgA ELISAs of eukaryotic recombinant proteins of desmocollins 1-3 are more sensitive and specific than baculoprotein ELISAs

新开发的桥粒胶蛋白 1-3 真核重组蛋白 IgA ELISA 比杆状蛋白 ELISA 更灵敏、更特异

• 发表时间: 2012
• 作者: Teye K;Ishii N;Koga H;Hamada T;Karashima T;Numata S;Ohata C;Furumura;M;Hashimoto T
• 通讯作者: Hashimoto T

Newly developed enzyme-linked immunosorbent assays using eukaryotic recombinant proteins of desmocollins (Dsc) are highly sensitive and revealed Dsc2 and Dsc3 as autoantigens specific for paraneoplastic pemphigus

新开发的使用桥粒胶蛋白 (Dsc) 真核重组蛋白的酶联免疫吸附测定法具有高度敏感性，并显示 Dsc2 和 Dsc3 是副肿瘤性天疱疮特异性的自身抗原

• 发表时间: 2012
• 作者: Norito Ishii;Shunpei Fukuda;Kwesi Teye;Atsunari Tsuchisaka;Takahiro Hamada;Daisuke Tsuruta;Teruki Dainichi;Takashi Hashimoto
• 通讯作者: Takashi Hashimoto

Takashi HashimotoNewly developed enzyme-linked immunosorbent assays using eukaryotic recombinant proteins of desmocollins (Dsc) are highly sensitive and revealed Dsc2 and Dsc3 as autoantigens specific for paraneoplastic pemphigus

Takashi Hashimoto 使用桥粒胶蛋白 (Dsc) 真核重组蛋白新开发的酶联免疫吸附测定法具有高度敏感性，并显示 Dsc2 和 Dsc3 是副肿瘤性天疱疮特异性自身抗原

• 发表时间: 2012
• 作者: Norito Ishii;Shunpei Fukuda;Kwesi Teye;Atsunari Tsuchisaka;Takahiro Hamada;Daisuke Tsuruta;Teruki Dainichi
• 通讯作者: Teruki Dainichi

Concurrence of bullous pemphigoid and herpetiform pemphigus with igg antibodies to desmogleins 1/3 and desmocollins 1-3.

大疱性类天疱疮和疱疹样天疱疮同时伴有桥粒芯蛋白 1/3 和桥粒芯蛋白 1-3 的 igg 抗体。

• DOI: 10.1111/bjd.12019
• 发表时间: 2012
• 期刊: Br J Dermatol
• 作者: Ohata C;Koga H;Teye K;Ishii N;Hamada T;Dainichi T;Furumura M;Sato M;Sueki H;Hashimoto T.
• 通讯作者: Hashimoto T.

Novel adenosine triphosphate (ATP)-binding cassette, subfamily A, member 12 (ABCA12) mutations associated with congenital ichthyosiform erythroderma. Br

与先天性鱼鳞病样红皮病相关的新型三磷酸腺苷 (ATP) 结合盒、A 亚家族、成员 12 (ABCA12) 突变。

• DOI: 10.1111/j.1365-2133.2011.10516.x
• 发表时间: 2012
• 期刊: J Dermatol
• 影响因子: 3.1
• 作者: Fukuda S;Hamada T;Ishii N;Sakaguchi S;Sakai K;Akiyama M;Shimizu H;Masuda K;Izu K;Teye K;Tsuruta D;Karashima T;Nakama T;Yasumoto S;Hashimoto T.
• 通讯作者: Hashimoto T.