Study on potentiation of neurite outgrowth by an atypical antipsychotic
Study on potentiation of neurite outgrowth by an atypical antipsychotic
批准号:
23791308
负责人:
ISHIMA Tamaki
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Aripiprazole significantly potentiated nerve growth factor(NGF)-induced neurite outgrowth in PC12 cells, in a concentration-dependent manner. The 5-HT1A receptor antagonist WAY-100635, but not the dopamine D2 receptor antagonistsulpiride, blocked the effects of aripiprazole, although, only partially. Specificinhibitors of several common signaling pathways also blocked the effects of aripiprazole.Using proteomic analysis, we found that aripiprazole significantly increased levels ofthe heat shock protein Hsp90α in cultured cells.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1038/tp.2012.97
发表时间:
2012-10-16
期刊:
Translational psychiatry
影响因子:
6.8
作者:
[Ishima T, Iyo M, Hashimoto K]
通讯作者:
Hashimoto K
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by aripiprazole
阿立哌唑增强神经生长因子诱导的 PC12 细胞神经突生长
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tamaki Ishima, Masaomi Iyo and Kenji Hashimoto]
通讯作者:
Masaomi Iyo and Kenji Hashimoto
DOI:
10.1371/journal.pone.0037989
发表时间:
2012
期刊:
PloS one
影响因子:
3.7
作者:
[Ishima T, Hashimoto K]
通讯作者:
Hashimoto K
Study on the etiology of bipolar disorder using iPS cells
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批准号:18K15507
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项目类别:Grant-in-Aid for Early-Career Scientists
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资助金额:$2.66万
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财政年份:2018
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负责人:ISHIMA Tamaki
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依托单位:
海外基金