Study on potentiation of neurite outgrowth by an atypical antipsychotic

非典型抗精神病药增强神经突生长的研究

• 批准号: 23791308
• 负责人: ISHIMA Tamaki
• 金额: $ 2.41万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791308/
• 关键词: 精神薬理学; 神経突起伸長; アリピプラゾール; カルシウムシグナリング; 熱ストレスタンパク質; IP3受容体

Aripiprazole significantly potentiated nerve growth factor(NGF)-induced neurite outgrowth in PC12 cells, in a concentration-dependent manner. The 5-HT1A receptor antagonist WAY-100635, but not the dopamine D2 receptor antagonistsulpiride, blocked the effects of aripiprazole, although, only partially. Specificinhibitors of several common signaling pathways also blocked the effects of aripiprazole.Using proteomic analysis, we found that aripiprazole significantly increased levels ofthe heat shock protein Hsp90α in cultured cells.

阿立哌唑以浓度依赖性方式显著增强神经生长因子（NGF）诱导的PC 12细胞神经突起生长。5-HT 1A受体拮抗剂WAY-100635（而非多巴胺D2受体拮抗剂舒必利）可部分阻断阿立哌唑的作用。几种常见信号通路的特异性抑制剂也阻断了阿立哌唑的作用。通过蛋白质组学分析，我们发现阿立哌唑显著增加了培养细胞中热休克蛋白Hsp 90 α的水平。

项目成果

Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole.

• DOI: 10.1038/tp.2012.97
• 发表时间: 2012-10-16
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Ishima T;Iyo M;Hashimoto K
• 通讯作者: Hashimoto K

Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by aripiprazole

阿立哌唑增强神经生长因子诱导的 PC12 细胞神经突生长

• 发表时间: 2012
• 作者: Tamaki Ishima;Masaomi Iyo and Kenji Hashimoto
• 通讯作者: Masaomi Iyo and Kenji Hashimoto

Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors.

• DOI: 10.1371/journal.pone.0037989
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Ishima T;Hashimoto K
• 通讯作者: Hashimoto K