Development of noninvasive imaging biomarker for early diagnosis and prediction of outcome of intractable diseases of the central nervous system

开发用于中枢神经系统疑难疾病早期诊断和预后预测的无创成像生物标志物

• 批准号: 23791380
• 负责人: THA KHIN KHIN
• 金额: $ 2.66万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791380/
• 关键词: 拡散テンソル; 神経難病; 頚髄; 脳; MRI

This study evaluated if the major diffusion tensor imaging (DTI) metrics of the brain and the spinal cord can become the quantitative metrics for noninvasive evaluation of intractable diseases of the central nervous system.Significant alterations in the major DTI metrics were observed in sporadic amyotrophic lateral sclerosis, multiple sclerosis, and neuromyelitis optica spectrum disorders, despite no abnormality on the routine MRI sequences. The abnormalities detected on DTI are thought to reflect axonal loss and/ or demyelination. In sporadic amyotrophic lateral sclerosis, the DTI abnormalities correlated strongly with the scores which determine disease severity or progression. In conclusion, DTI is considered a sensitive technique to detect the microstructural abnormalities of the brain and the spinal cord in the intractable diseases of the central nervous system; and can be used to noninvasively quantify the severity or progression of these diseases.

本研究评估脑和脊髓的主要弥散张量成像（DTI）指标是否可以成为中枢神经系统难治性疾病无创评估的定量指标。在散发性肌萎缩性侧索硬化症、多发性硬化症和视神经脊髓炎谱系障碍患者中，尽管常规MRI序列未见异常，但主要DTI指标有显著改变。在DTI上检测到的异常被认为反映了轴突丢失和/或脱髓鞘。在散发性肌萎缩性侧索硬化症中，DTI异常与决定疾病严重程度或进展的评分密切相关。综上所述，DTI被认为是一种敏感的技术，可以检测中枢神经系统顽固性疾病中脑和脊髓的显微结构异常；并可用于无创量化这些疾病的严重程度或进展。

项目成果

小脳白質ー解剖と疾患（仮）

小脑白质 - 解剖学和疾病（暂定）

• 作者: Tha KK;Terae S;Hamaguchi H;Ishizaka K;Popy KA;Hirotani M;Minowa K;Suzuki Y;Shirato H;タキンキン
• 通讯作者: タキンキン

The ascending sensory pathways may not be spared in amyotrophic lateral sclerosis

肌萎缩侧索硬化症患者的上行感觉通路可能无法幸免

• 发表时间: 2013
• 作者: Tha KK;Yabe I;Terae S;Hirotani M;Hamaguchi H;Ishizaka K;Suzuki Y;Okuaki T;Minowa K;Sasaki H;Shirato H
• 通讯作者: Shirato H

Laterality of the corticospinal tract and the influence of handedness : the findings of a DTI study

皮质脊髓束的偏侧性和惯用手的影响：DTI 研究的结果

• 发表时间: 2013
• 期刊: 日本磁気共鳴医学会雑誌
• 作者: Tha KK;Terae S;Hamaguchi H;Ishizaka K;Popy KA;Hirotani M;Sugimori H;Fujima N;Yoshida A;Minowa K;Suzuki Y;Shirato H.
• 通讯作者: Shirato H.

体内水分子の拡散を非侵襲的に観察するMRI撮像法 : 現状と将来展望

非侵入性观察体内水分子扩散的MRI成像方法：现状与未来展望

• 发表时间: 2013
• 作者: 堀弘明;功刀浩;Tha KK
• 通讯作者: Tha KK

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