Elucidation of the transcription factor network that regulates cancer-stroma interaction

间质和癌细胞之间的相互作用似乎对癌症的发展至关重要。然而，很少有人知道基质细胞的功能是如何在基因表达水平上调节的。在这个项目中，我们专注于转录因子Bach 1，我们有几个初步的观察表明它在癌症-间质相互作用中的重要作用。我们发现Bach 1在几种小鼠模型系统中对肿瘤形成至关重要。我们确定了Bach 1的下游基因，这些基因似乎对基质功能至关重要。我们还研究了BACH 1在人基质细胞中的调节。这些结果将为进一步研究肿瘤-间质相互作用奠定重要基础。

Interaction between stroma and cancer cells appears critical for the development of cancer. However, little is known about how the functions of stroma cells are regulated at the level of gene expression. In this project, we focused on the transcription factor Bach1 on which we had several preliminary observations suggesting its important roles in the cancer-stroma interaction. We found that Bach1 is critical for tumor formation in several mouse model systems. We identified downstream genes of Bach1 which appeared to be critical for the stroma function. We also studied the regulation of BACH1 in human stroma cells. These results will be an important foundation for future studies on the cancer-stroma interaction.