Elucidation of the transcription factor network that regulates cancer-stroma interaction

阐明调节癌症-基质相互作用的转录因子网络

• 批准号: 23659168
• 负责人: IGARASHI Kazuhiko
• 金额: $ 2.41万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659168/
• 关键词: 分子腫瘍学; 転写因子; ケモカイン; サイトカイン; Bach1

Interaction between stroma and cancer cells appears critical for the development of cancer. However, little is known about how the functions of stroma cells are regulated at the level of gene expression. In this project, we focused on the transcription factor Bach1 on which we had several preliminary observations suggesting its important roles in the cancer-stroma interaction. We found that Bach1 is critical for tumor formation in several mouse model systems. We identified downstream genes of Bach1 which appeared to be critical for the stroma function. We also studied the regulation of BACH1 in human stroma cells. These results will be an important foundation for future studies on the cancer-stroma interaction.

间质和癌细胞之间的相互作用似乎对癌症的发展至关重要。然而，很少有人知道基质细胞的功能是如何在基因表达水平上调节的。在这个项目中，我们专注于转录因子Bach 1，我们有几个初步的观察表明它在癌症-间质相互作用中的重要作用。我们发现Bach 1在几种小鼠模型系统中对肿瘤形成至关重要。我们确定了Bach 1的下游基因，这些基因似乎对基质功能至关重要。我们还研究了BACH 1在人基质细胞中的调节。这些结果将为进一步研究肿瘤-间质相互作用奠定重要基础。

项目成果

Identification of Senescence-Associated Genes and Their Networks Under Oxidative Stress by the Analysis of Bach1

• DOI: 10.1089/ars.2010.3574
• 发表时间: 2011-06-01
• 期刊: ANTIOXIDANTS & REDOX SIGNALING
• 影响因子: 6.6
• 作者: Ota, Kazushige;Dohi, Yoshihiro;Igarashi, Kazuhiko
• 通讯作者: Igarashi, Kazuhiko

Bach1 as a regulat or mitosis, beyond its transcriptional function

Bach1 作为调节剂或有丝分裂，超出其转录功能

• 发表时间: 2012
• 期刊: Commun Integr Biology
• 作者: Li J;Shiraki T;Igarashi K
• 通讯作者: Igarashi K

The role of transcription factor Bach1 in cancer-stroma interaction （がんと間質の相互作用における転写因子Bach1の意義）

转录因子 Bach1 在癌症-基质相互作用中的作用

• 发表时间: 2011
• 作者: Fujimoto;T.;Yoshimoto;K.;Itaya-Hironaka;A.;Yamauchi;A.;Sakuramoto-Tsuchida;S.;Miyaoka;T.;Takeda;M.;Kasai;T.;Nonomura;A.;Tanaka;Y. and Takasawa;S.;BRYDUN ANDREY
• 通讯作者: BRYDUN ANDREY

The role of transcription factor Bach1 in cancer-stroma interaction(がんと間質の相互作用における転写因子 Bach1 の意義)

转录因子 Bach1 在癌症-基质相互作用中的作用

• 发表时间: 2011
• 作者: 吉本清巳;藤本 隆;広中安佐子;宮岡朋子;土田澄代;山内晶世;武田麻衣子;笠井孝彦;野々村昭孝;高沢 伸;本橋ほづみ;BRYDUN ANDREY
• 通讯作者: BRYDUN ANDREY

Bach1-mediated suppression of p53 is inhibited by p19ARF independently of MDM2

• DOI: 10.1111/j.1349-7006.2012.02244.x
• 发表时间: 2012-05-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Nishizawa, Hironari;Ota, Kazushige;Igarashi, Kazuhiko
• 通讯作者: Igarashi, Kazuhiko