Regulation of gene transcription and nuclear structure by architectural transcription factors
Regulation of gene transcription and nuclear structure by architectural transcription factors
批准号:
13470024
负责人:
IGARASHI Kazuhiko
金额:
$8.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2002
中文摘要
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英文摘要
We found :1. Binding of Bach1 to the globin LCR is regulated by heme, the prothetic group of hemoglobin.2. Heme oxygenase-1 (HO-1) is another physiological target gene of Bach1.3. Heme regulates binding of Bach1 to the LCR of HO-1 gene through direct binding to Bach1. The BTB domain of Bach1 is essential for the Bach1 binding to the HO-1 LCR.4. Bach1 regulates HO-1 gene expression through mechanisms that are distinct from regulation of histone acetylation-deacetylation.5. Bach2 accumulates within the PML nuclear bodies to repress gene expression there.6. The BTB domain of Bach2 is essential for the targeting of Bach2 to PML bodies.
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Ogawa, K.: "Heme mediates de-repression of Maf recognition element through direct binding to transcription repressor Bach1"EMBO J.. 20. 2835-2843 (2001)
小川,K.:“血红素通过直接结合转录抑制因子 Bach1 介导 Maf 识别元件的去抑制”EMBO J.. 20. 2835-2843 (2001)
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Sun, J.: "Hemoprotein Bach 1 regulates enhancer availability of heme oxygenase-1 gene"EMBO J.. 21. 5216-5224 (2002)
Sun, J.:“血红素蛋白 Bach 1 调节血红素加氧酶-1 基因的增强剂可用性”EMBO J.. 21. 5216-5224 (2002)
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Tanabe, O.: "Fission yeast homologues of the B' subunit of protein phosphatase 2A : multiple roles in mitotic cell division and functional interaction with calcineurin"Genes Cells. 6. 455-474 (2001)
Tanabe, O.:“蛋白磷酸酶 2A B 亚基的裂殖酵母同源物:在有丝分裂细胞分裂和与钙调神经磷酸酶功能相互作用中的多种作用”Genes Cells。
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Katsuoka, F.: "Small Maf compound mutants display central nervous system neuronal degeneration, aberrant transcription, and Bach protein mislocalization coincident with myoclonus and abnormal startle response"Mol. Cell Biol.. 3. 1163-1174 (2003)
Katsuoka, F.:“小 Maf 复合突变体表现出中枢神经系统神经元变性、异常转录和巴赫蛋白错误定位,与肌阵挛和异常惊吓反应一致”Mol。
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Sun, J.: "Promoter of Mouse Transcription Repressor bach1 Is Regulated by Sp1 and Trans-Activated by Bach1"J. Biochem.. 130. 385-392 (2001)
Sun, J.:“小鼠转录抑制子 bach1 的启动子受 Sp1 调节并由 Bach1 反式激活”J.
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共 14 条
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Comparative Analysis of the DECODE Systems in Hematopoiesis and Oxidative Stress Response
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Regulation of hematopoiesis by the transcription factors Bach1 and Bach2
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Regulation of cell proliferation ancl apoptcsis by the nansaiption factois Bach1 and Bach2
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Regulation of chromatin structures during hematopoietic cell differentiation
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Regulation of chromatin structures and hematopoietic cell differentiation by architectural transcription factors Bach1 and Bach2
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REGULATION OF CELL PROLIFERATION BY CROSS-TALK OF BACH AND AP-1 TRANSCRIPTION FACTORS.
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财政年份:1999
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GENETIC CONTROL OF HEMATOPOIETIC CELL DOFFERENTIATION
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REGULATION OF DIFFERENTIATION BY BACH TRANSCRIPTION FACTORS
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海外基金