课题基金 / 基金详情

Regulation of gene transcription and nuclear structure by architectural transcription factors

Regulation of gene transcription and nuclear structure by architectural transcription factors
结构转录因子对基因转录和核结构的调节
批准号:
13470024
负责人:
IGARASHI Kazuhiko
金额:
$8.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2002

项目摘要

项目成果

IGARASHI Kazuhiko的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
We found :1. Binding of Bach1 to the globin LCR is regulated by heme, the prothetic group of hemoglobin.2. Heme oxygenase-1 (HO-1) is another physiological target gene of Bach1.3. Heme regulates binding of Bach1 to the LCR of HO-1 gene through direct binding to Bach1. The BTB domain of Bach1 is essential for the Bach1 binding to the HO-1 LCR.4. Bach1 regulates HO-1 gene expression through mechanisms that are distinct from regulation of histone acetylation-deacetylation.5. Bach2 accumulates within the PML nuclear bodies to repress gene expression there.6. The BTB domain of Bach2 is essential for the targeting of Bach2 to PML bodies.
期刊论文(48)
专著(0)
科研奖励(0)
会议论文
Ogawa, K.: "Heme mediates de-repression of Maf recognition element through direct binding to transcription repressor Bach1"EMBO J.. 20. 2835-2843 (2001)
小川,K.:“血红素通过直接结合转录抑制因子 Bach1 介导 Maf 识别元件的去抑制”EMBO J.. 20. 2835-2843 (2001)
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Sun, J.: "Hemoprotein Bach 1 regulates enhancer availability of heme oxygenase-1 gene"EMBO J.. 21. 5216-5224 (2002)
Sun, J.:“血红素蛋白 Bach 1 调节血红素加氧酶-1 基因的增强剂可用性”EMBO J.. 21. 5216-5224 (2002)
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Tanabe, O.: "Fission yeast homologues of the B' subunit of protein phosphatase 2A : multiple roles in mitotic cell division and functional interaction with calcineurin"Genes Cells. 6. 455-474 (2001)
Tanabe, O.:“蛋白磷酸酶 2A B 亚基的裂殖酵母同源物:在有丝分裂细胞分裂和与钙调神经磷酸酶功能相互作用中的多种作用”Genes Cells。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Katsuoka, F.: "Small Maf compound mutants display central nervous system neuronal degeneration, aberrant transcription, and Bach protein mislocalization coincident with myoclonus and abnormal startle response"Mol. Cell Biol.. 3. 1163-1174 (2003)
Katsuoka, F.:“小 Maf 复合突变体表现出中枢神经系统神经元变性、异常转录和巴赫蛋白错误定位,与肌阵挛和异常惊吓反应一致”Mol。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
14
    Age-related alterations of hematopoietic stem and progenitor cells due to failure of Bach transcription factors
    • 批准号:
      18H04021
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $28.54万
    • 财政年份:
      2018
    • 负责人:
      IGARASHI Kazuhiko
    • 依托单位:
    Development of a new strategy for tumor immunity activation
    • 批准号:
      16K15227
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2016
    • 负责人:
      IGARASHI Kazuhiko
    • 依托单位:
    Regulation of erythropoiesis and macrophages by the heme signal
    • 批准号:
      15H02506
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $29.62万
    • 财政年份:
      2015
    • 负责人:
      IGARASHI Kazuhiko
    • 依托单位:
    Elucidation of the transcription factor network that regulates cancer-stroma interaction
    • 批准号:
      23659168
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2011
    • 负责人:
      IGARASHI Kazuhiko
    • 依托单位:
    海外基金