Spatiotemporal control of allergy and non-infectious inflammation and their regulation by natural products

过敏和非感染性炎症的时空控制及其天然产物的调节

• 批准号: 23659247
• 负责人: TAKATSU Kiyoshi
• 金额: $ 2.41万
• 依托单位: Toyama Prefectural Institute. for Pharmaceutical Research.
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659247/
• 关键词: アレルギー; 免疫関連疾患; 自然免疫; 非感染性慢性炎症; TLR; 天然物; 肥満; 糖尿病; IL-5

(1) We identified innate IL-5-producing cells by using the IL-5 reporter mice.(2) RP105 expression dramatically increased in the adipose tissue from high-fat diet fed mice and obese subjects.(3) We established assay systems useful for analyzing immune regulation, and evaluated the natural compounds for their regulatory effects on the immune system. As a result, we identified several compounds as medicinal seeds useful for an allergy medication, an immune-stimulator, and an anti-diabetic drug.(4) We find mechanisms, in part, by which these compounds regulate the immune system.

(1)我们通过使用IL-5报告小鼠鉴定了先天性IL-5产生细胞。(2)RP 105表达在来自高脂肪饮食喂养的小鼠和肥胖受试者的脂肪组织中显著增加。(3)我们建立了用于分析免疫调节的测定系统，并评估了天然化合物对免疫系统的调节作用。结果，我们鉴定了几种化合物作为药用种子，可用于过敏药物、免疫刺激剂和抗糖尿病药物。(4)我们发现了这些化合物调节免疫系统的部分机制。

项目成果

Identification of Innate IL-5-Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity

• DOI: 10.4049/jimmunol.1101270
• 发表时间: 2012-01-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Ikutani, Masashi;Yanagibashi, Tsutomu;Takatsu, Kiyoshi
• 通讯作者: Takatsu, Kiyoshi

The RP105/MD-1 complex plays critical roles in diet-induced obesity and adipose tissue inflammation independent of palmitate-TLR4 signaling

RP105/MD-1 复合物在饮食诱导的肥胖和脂肪组织炎症中发挥着关键作用，不依赖于棕榈酸酯-TLR4 信号传导

• 发表时间: 2011
• 作者: R. Murakami;H. Takagi;T. Fukaya;O. Ohara;T. Kaisho;B. Malissen;K. Sato.;長井良憲
• 通讯作者: 長井良憲

The major IL-5-producing cells in the intestine and lung are c-kit+CD3ε-cells

肠和肺中主要产生 IL-5 的细胞是 c-kit+CD3ε-细胞

• 发表时间: 2011
• 作者: Tsukamoto;Y.;et al.;刈米アイ;刈米アイ;小笠原勝;柳橋努
• 通讯作者: 柳橋努

Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll-like receptor 4/MD-2 complex signaling in a different manner

• DOI: 10.1189/jlb.0112038
• 发表时间: 2012-06-01
• 期刊: JOURNAL OF LEUKOCYTE BIOLOGY
• 影响因子: 5.5
• 作者: Honda, Hiroe;Nagai, Yoshinori;Takatsu, Kiyoshi
• 通讯作者: Takatsu, Kiyoshi

The RP105/MD-1 complex plays critical roles in diet-induced obesity and adipose tissue inflammation independent of palmitate-TLR4 signaling.

RP105/MD-1 复合物在饮食诱导的肥胖和脂肪组织炎症中发挥着关键作用，不依赖于棕榈酸酯-TLR4 信号传导。

• 发表时间: 2011
• 作者: Nagai Y.; Watanabe Y.; Nakamura T.; Ikutani M.; Kariyone A.; Akira S.; Miyake K. and Takatsu K.
• 通讯作者: Miyake K. and Takatsu K.