Spatiotemporal control of allergy and non-infectious inflammation and their regulation by natural products
过敏和非感染性炎症的时空控制及其天然产物的调节
基本信息
- 批准号:23659247
- 负责人:
- 金额:$ 2.41万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Challenging Exploratory Research
- 财政年份:2011
- 资助国家:日本
- 起止时间:2011 至 2012
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
(1) We identified innate IL-5-producing cells by using the IL-5 reporter mice.(2) RP105 expression dramatically increased in the adipose tissue from high-fat diet fed mice and obese subjects.(3) We established assay systems useful for analyzing immune regulation, and evaluated the natural compounds for their regulatory effects on the immune system. As a result, we identified several compounds as medicinal seeds useful for an allergy medication, an immune-stimulator, and an anti-diabetic drug.(4) We find mechanisms, in part, by which these compounds regulate the immune system.
(1)利用IL-5报告鼠鉴定天然产生IL-5的细胞。(2)高脂饮食喂养的小鼠和肥胖受试者的脂肪组织中RP105的表达显著增加。(3)我们建立了可用于分析免疫调节的检测体系,并评价了天然化合物对免疫系统的调节作用。结果,我们确定了几种化合物作为药物种子,可用于过敏药物、免疫刺激剂和抗糖尿病药物。(4)我们发现了这些化合物调节免疫系统的部分机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Identification of Innate IL-5-Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity
- DOI:10.4049/jimmunol.1101270
- 发表时间:2012-01-15
- 期刊:
- 影响因子:4.4
- 作者:Ikutani, Masashi;Yanagibashi, Tsutomu;Takatsu, Kiyoshi
- 通讯作者:Takatsu, Kiyoshi
The RP105/MD-1 complex plays critical roles in diet-induced obesity and adipose tissue inflammation independent of palmitate-TLR4 signaling
RP105/MD-1 复合物在饮食诱导的肥胖和脂肪组织炎症中发挥着关键作用,不依赖于棕榈酸酯-TLR4 信号传导
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:R. Murakami;H. Takagi;T. Fukaya;O. Ohara;T. Kaisho;B. Malissen;K. Sato.;長井良憲
- 通讯作者:長井良憲
The major IL-5-producing cells in the intestine and lung are c-kit+CD3ε-cells
肠和肺中主要产生 IL-5 的细胞是 c-kit+CD3ε-细胞
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Tsukamoto;Y.;et al.;刈米アイ;刈米アイ;小笠原勝;柳橋努
- 通讯作者:柳橋努
Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll-like receptor 4/MD-2 complex signaling in a different manner
- DOI:10.1189/jlb.0112038
- 发表时间:2012-06-01
- 期刊:
- 影响因子:5.5
- 作者:Honda, Hiroe;Nagai, Yoshinori;Takatsu, Kiyoshi
- 通讯作者:Takatsu, Kiyoshi
The RP105/MD-1 complex plays critical roles in diet-induced obesity and adipose tissue inflammation independent of palmitate-TLR4 signaling.
RP105/MD-1 复合物在饮食诱导的肥胖和脂肪组织炎症中发挥着关键作用,不依赖于棕榈酸酯-TLR4 信号传导。
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Nagai Y.; Watanabe Y.; Nakamura T.; Ikutani M.; Kariyone A.; Akira S.; Miyake K. and Takatsu K.
- 通讯作者:Miyake K. and Takatsu K.
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TAKATSU Kiyoshi其他文献
TAKATSU Kiyoshi的其他文献
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{{ truncateString('TAKATSU Kiyoshi', 18)}}的其他基金
Analysis of innate IL-5 producing cells in immune responses and chronic inflammation
免疫反应和慢性炎症中先天性 IL-5 产生细胞的分析
- 批准号:
24390119 - 财政年份:2012
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Roles of cytokines and TLRs in lymphocyte activation and differentiation
细胞因子和 TLR 在淋巴细胞活化和分化中的作用
- 批准号:
20390141 - 财政年份:2008
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Enhancement of Th1 and antitumor immunity by Ag85B and Peptide-25.
Ag85B 和 Peptide-25 增强 Th1 和抗肿瘤免疫力。
- 批准号:
17013024 - 财政年份:2005
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Investigation of regulatory mechanisms for homeostasis and activation of lymphocyte
淋巴细胞稳态和激活调节机制的研究
- 批准号:
16109004 - 财政年份:2004
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (S)
REGULATORY MECHANISMS OF IL-5 DEPENDENT IMMUNE REGULATION
IL-5依赖性免疫调节的调节机制
- 批准号:
13307012 - 财政年份:2001
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Molecular mechanisms of isotype switch recombination.
同型转换重组的分子机制。
- 批准号:
11470083 - 财政年份:1999
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
Molecular mechanisms of oral immunity : Role of IL-5 in potentiation of IgA production in mucosal lymphoid cell
口腔免疫的分子机制:IL-5 在增强粘膜淋巴细胞 IgA 产生中的作用
- 批准号:
10557036 - 财政年份:1998
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecular mechanisms of proliferation and differentiation of germinal center B cells
生发中心B细胞增殖分化的分子机制
- 批准号:
09470091 - 财政年份:1997
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Signaling through surface receptors in immune cells.
通过免疫细胞表面受体发出信号。
- 批准号:
09044263 - 财政年份:1997
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for international Scientific Research
Molecular Mechanisms and Intervention of Immunological Diseases.
免疫疾病的分子机制和干预。
- 批准号:
08282101 - 财政年份:1996
- 资助金额:
$ 2.41万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
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- 资助金额:
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The role of PRMT1 signal on immune response and immune related disease
PRMT1信号对免疫反应和免疫相关疾病的作用
- 批准号:
24590286 - 财政年份:2012
- 资助金额:
$ 2.41万 - 项目类别:
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对群体基因组学产生的免疫相关疾病的见解
- 批准号:
8105084 - 财政年份:2010
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$ 2.41万 - 项目类别:
Insights into immune-related disease born from population genomics
对群体基因组学产生的免疫相关疾病的见解
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- 资助金额:
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$ 2.41万 - 项目类别:
Insights into immune-related disease born from population genomics
对群体基因组学产生的免疫相关疾病的见解
- 批准号:
7992673 - 财政年份:2010
- 资助金额:
$ 2.41万 - 项目类别:
Insights into immune-related disease born from population genomics
对群体基因组学产生的免疫相关疾病的见解
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8676643 - 财政年份:2010
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$ 2.41万 - 项目类别:
Insights into immune-related disease born from population genomics
对群体基因组学产生的免疫相关疾病的见解
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$ 2.41万 - 项目类别:
Insights into immune-related disease born from population genomics
对群体基因组学产生的免疫相关疾病的见解
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9100613 - 财政年份:2010
- 资助金额:
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