Spatiotemporal control of allergy and non-infectious inflammation and their regulation by natural products
Spatiotemporal control of allergy and non-infectious inflammation and their regulation by natural products
批准号:
23659247
负责人:
TAKATSU Kiyoshi
金额:
$2.41万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
(1) We identified innate IL-5-producing cells by using the IL-5 reporter mice.(2) RP105 expression dramatically increased in the adipose tissue from high-fat diet fed mice and obese subjects.(3) We established assay systems useful for analyzing immune regulation, and evaluated the natural compounds for their regulatory effects on the immune system. As a result, we identified several compounds as medicinal seeds useful for an allergy medication, an immune-stimulator, and an anti-diabetic drug.(4) We find mechanisms, in part, by which these compounds regulate the immune system.
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DOI:
10.4049/jimmunol.1101270
发表时间:
2012-01-15
期刊:
JOURNAL OF IMMUNOLOGY
影响因子:
4.4
作者:
[Ikutani, Masashi, Yanagibashi, Tsutomu, Takatsu, Kiyoshi]
通讯作者:
Takatsu, Kiyoshi
The RP105/MD-1 complex plays critical roles in diet-induced obesity and adipose tissue inflammation independent of palmitate-TLR4 signaling
RP105/MD-1 复合物在饮食诱导的肥胖和脂肪组织炎症中发挥着关键作用,不依赖于棕榈酸酯-TLR4 信号传导
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[R. Murakami, H. Takagi, T. Fukaya, O. Ohara, T. Kaisho, B. Malissen, K. Sato., 長井良憲]
通讯作者:
長井良憲
The major IL-5-producing cells in the intestine and lung are c-kit+CD3ε-cells
肠和肺中主要产生 IL-5 的细胞是 c-kit+CD3ε-细胞
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tsukamoto, Y., et al., 刈米アイ, 刈米アイ, 小笠原勝, 柳橋努]
通讯作者:
柳橋努
DOI:
10.1189/jlb.0112038
发表时间:
2012-06-01
期刊:
JOURNAL OF LEUKOCYTE BIOLOGY
影响因子:
5.5
作者:
[Honda, Hiroe, Nagai, Yoshinori, Takatsu, Kiyoshi]
通讯作者:
Takatsu, Kiyoshi
The RP105/MD-1 complex plays critical roles in diet-induced obesity and adipose tissue inflammation independent of palmitate-TLR4 signaling.
RP105/MD-1 复合物在饮食诱导的肥胖和脂肪组织炎症中发挥着关键作用,不依赖于棕榈酸酯-TLR4 信号传导。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nagai Y., Watanabe Y., Nakamura T., Ikutani M., Kariyone A., Akira S., Miyake K. and Takatsu K.]
通讯作者:
Miyake K. and Takatsu K.
共 13 条
Analysis of innate IL-5 producing cells in immune responses and chronic inflammation
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批准号:24390119
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.73万
-
财政年份:2012
-
负责人:TAKATSU Kiyoshi
-
依托单位:
Roles of cytokines and TLRs in lymphocyte activation and differentiation
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批准号:20390141
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.73万
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财政年份:2008
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负责人:TAKATSU Kiyoshi
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依托单位:
Enhancement of Th1 and antitumor immunity by Ag85B and Peptide-25.
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批准号:17013024
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$34.24万
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财政年份:2005
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负责人:TAKATSU Kiyoshi
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依托单位:
Investigation of regulatory mechanisms for homeostasis and activation of lymphocyte
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批准号:16109004
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$63.65万
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财政年份:2004
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负责人:TAKATSU Kiyoshi
-
依托单位:
REGULATORY MECHANISMS OF IL-5 DEPENDENT IMMUNE REGULATION
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批准号:13307012
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$35.36万
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财政年份:2001
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负责人:TAKATSU Kiyoshi
-
依托单位:
Molecular mechanisms of isotype switch recombination.
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批准号:11470083
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$9.22万
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财政年份:1999
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负责人:TAKATSU Kiyoshi
-
依托单位:
Molecular mechanisms of oral immunity : Role of IL-5 in potentiation of IgA production in mucosal lymphoid cell
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批准号:10557036
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.36万
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财政年份:1998
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负责人:TAKATSU Kiyoshi
-
依托单位:
Molecular mechanisms of proliferation and differentiation of germinal center B cells
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批准号:09470091
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.51万
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财政年份:1997
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负责人:TAKATSU Kiyoshi
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依托单位:
Signaling through surface receptors in immune cells.
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批准号:09044263
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$3.46万
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财政年份:1997
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负责人:TAKATSU Kiyoshi
-
依托单位:
Molecular Mechanisms and Intervention of Immunological Diseases.
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批准号:08282101
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$38.46万
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财政年份:1996
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负责人:TAKATSU Kiyoshi
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依托单位:
Signal transduction through cell surface receptors
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批准号:07044225
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$3.71万
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财政年份:1995
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负责人:TAKATSU Kiyoshi
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依托单位:
Mechanism of pathogenesis of chronic inflamation
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批准号:07557030
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$8.32万
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财政年份:1995
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负责人:TAKATSU Kiyoshi
-
依托单位:
Studies on the mechanisms of the maturation of germinal center B cells.
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批准号:05404024
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$18.18万
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财政年份:1993
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负责人:TAKATSU Kiyoshi
-
依托单位:
MECHANISM OF PATHOGENESIS OF LATE-PHASE ASTHMATIC RESPONSE (LAR) : PREVENTIVE EFFECT OF ANTI-IL-5 ANTIBODY ON LAR IN ANIMAL MODEL
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批准号:05557023
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$8.13万
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财政年份:1993
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负责人:TAKATSU Kiyoshi
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依托单位:
MECHANISMS OF SIGNAL TRANSDUCTION THROUGH SURFACE RECEPTORS
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批准号:04044135
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$5.44万
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财政年份:1992
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负责人:TAKATSU Kiyoshi
-
依托单位:
Role of IL-5 and Receptor System in the Regulation of the Immune System and Inflammatory Response.
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批准号:02404033
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$11.39万
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财政年份:1990
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负责人:TAKATSU Kiyoshi
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依托单位:
Regulatory Role of Interleukin 5 and Its Receptor in the Bcell Growth and Differentiation
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批准号:01044115
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$5.57万
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财政年份:1989
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负责人:TAKATSU Kiyoshi
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依托单位:
SIGNAL TRANSDUCTION THROUGH CYTOKINES AND THEIR RECEPTOR FOR B CELL GROWTH AND DIFFERENTIATION
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批准号:63480171
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1988
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负责人:TAKATSU Kiyoshi
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依托单位:
Regulation of B cell growth and differentiation and immune abnormality
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批准号:61480159
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.1万
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财政年份:1986
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负责人:TAKATSU Kiyoshi
-
依托单位:
海外基金