Spatiotemporal control of allergy and non-infectious inflammation and their regulation by natural products

过敏和非感染性炎症的时空控制及其天然产物的调节

• 批准号: 23659247
• 负责人: TAKATSU Kiyoshi
• 金额: $ 2.41万
• 依托单位: Toyama Prefectural Institute. for Pharmaceutical Research.
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659247/
• 关键词: アレルギー; 免疫関連疾患; 自然免疫; 非感染性慢性炎症; TLR; 天然物; 肥満; 糖尿病; IL-5

(1) We identified innate IL-5-producing cells by using the IL-5 reporter mice.(2) RP105 expression dramatically increased in the adipose tissue from high-fat diet fed mice and obese subjects.(3) We established assay systems useful for analyzing immune regulation, and evaluated the natural compounds for their regulatory effects on the immune system. As a result, we identified several compounds as medicinal seeds useful for an allergy medication, an immune-stimulator, and an anti-diabetic drug.(4) We find mechanisms, in part, by which these compounds regulate the immune system.

(1)利用IL-5报告鼠鉴定天然产生IL-5的细胞。(2)高脂饮食喂养的小鼠和肥胖受试者的脂肪组织中RP105的表达显著增加。(3)我们建立了可用于分析免疫调节的检测体系，并评价了天然化合物对免疫系统的调节作用。结果，我们确定了几种化合物作为药物种子，可用于过敏药物、免疫刺激剂和抗糖尿病药物。(4)我们发现了这些化合物调节免疫系统的部分机制。

项目成果

Identification of Innate IL-5-Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity

• DOI: 10.4049/jimmunol.1101270
• 发表时间: 2012-01-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Ikutani, Masashi;Yanagibashi, Tsutomu;Takatsu, Kiyoshi
• 通讯作者: Takatsu, Kiyoshi

The RP105/MD-1 complex plays critical roles in diet-induced obesity and adipose tissue inflammation independent of palmitate-TLR4 signaling

RP105/MD-1 复合物在饮食诱导的肥胖和脂肪组织炎症中发挥着关键作用，不依赖于棕榈酸酯-TLR4 信号传导

• 发表时间: 2011
• 作者: R. Murakami;H. Takagi;T. Fukaya;O. Ohara;T. Kaisho;B. Malissen;K. Sato.;長井良憲
• 通讯作者: 長井良憲

The major IL-5-producing cells in the intestine and lung are c-kit+CD3ε-cells

肠和肺中主要产生 IL-5 的细胞是 c-kit+CD3ε-细胞

• 发表时间: 2011
• 作者: Tsukamoto;Y.;et al.;刈米アイ;刈米アイ;小笠原勝;柳橋努
• 通讯作者: 柳橋努

Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll-like receptor 4/MD-2 complex signaling in a different manner

• DOI: 10.1189/jlb.0112038
• 发表时间: 2012-06-01
• 期刊: JOURNAL OF LEUKOCYTE BIOLOGY
• 影响因子: 5.5
• 作者: Honda, Hiroe;Nagai, Yoshinori;Takatsu, Kiyoshi
• 通讯作者: Takatsu, Kiyoshi

The RP105/MD-1 complex plays critical roles in diet-induced obesity and adipose tissue inflammation independent of palmitate-TLR4 signaling.

RP105/MD-1 复合物在饮食诱导的肥胖和脂肪组织炎症中发挥着关键作用，不依赖于棕榈酸酯-TLR4 信号传导。

• 发表时间: 2011
• 作者: Nagai Y.; Watanabe Y.; Nakamura T.; Ikutani M.; Kariyone A.; Akira S.; Miyake K. and Takatsu K.
• 通讯作者: Miyake K. and Takatsu K.