Roles of cytokines and TLRs in lymphocyte activation and differentiation

细胞因子和 TLR 在淋巴细胞活化和分化中的作用

• 批准号: 20390141
• 负责人: TAKATSU Kiyoshi
• 金额: $ 12.73万
• 依托单位: University of Toyama
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390141/
• 关键词: リンパ球; IL-5; TLR; 抗原交叉提示; 免疫学; 自然免疫; IFN-γ; Iigp1

To investigate IL-5-producing cells in the peripheral tissues, we succeeded to generate IL-5/GFP knock-in mice. IL-5/GFP^+ cells were distributed mainly in the lung and intestinal tissues and they were CD3^- c-kit^- cells but not CD3^+ T cells. We also analyzed RP105 signals in B cell activation and found that RP105 was required for TLR4-dependent plasma cell differentiation and IgM production. Finally, we demonstrated that an interferon-inducible gene Iigp1 had a crucial role in Th1-dependent antigen cross-presentation.

为了研究周围组织中产生的IL-5产生细胞，我们成功地产生了IL-5/GFP敲击小鼠。 IL-5/GFP^+细胞主要分布在肺和肠道组织中，它们是CD3^-C-KIT^ - 细胞，而不是CD3^+ T细胞。我们还分析了B细胞激活中的RP105信号，发现RP105是TLR4依赖性的浆细胞分化和IgM产生所必需的。最后，我们证明了干扰素诱导的基因IIGP1在Th1依赖性抗原交叉呈递中具有至关重要的作用。

项目成果

Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokines-and integrin-mediated signals.

Lnk/Sh2b3 接头蛋白通过细胞因子和整合素介导的信号之间的串扰来调节巨核细胞的生长和成熟。

• 发表时间: 2008
• 期刊: Experimental Hematology Vol.36
• 作者: Takizawa H.;Takatsu K.
• 通讯作者: Takatsu K.

Identification of soluble MD-1 and its role in autoimmune diseases.

可溶性 MD-1 的鉴定及其在自身免疫性疾病中的作用。

• 发表时间: 2008
• 作者: Sasaki;S.
• 通讯作者: S.

An adaptor protein Lnk/Sh2B3, negative regulator of lymphohematopoiesis, contributes to the maintenance of gut-associated lymphoid tissues.

接头蛋白 Lnk/Sh2B3 是淋巴造血的负调节因子，有助于维持肠道相关淋巴组织。

• 发表时间: 2009
• 作者: Katayama;H.
• 通讯作者: H.

Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals

• DOI: 10.1016/j.exphem.2008.02.004
• 发表时间: 2008-07-01
• 期刊: EXPERIMENTAL HEMATOLOGY
• 影响因子: 2.6
• 作者: Takizawa, Hitoshi;Eto, Koji;Takaki, Satoshi
• 通讯作者: Takaki, Satoshi

Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis.

• DOI: 10.1084/jem.20091885
• 发表时间: 2010-07-05
• 期刊: The Journal of experimental medicine
• 作者: Shafiani S;Tucker-Heard G;Kariyone A;Takatsu K;Urdahl KB
• 通讯作者: Urdahl KB