Roles of cytokines and TLRs in lymphocyte activation and differentiation
Roles of cytokines and TLRs in lymphocyte activation and differentiation
批准号:
20390141
负责人:
TAKATSU Kiyoshi
金额:
$12.73万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
To investigate IL-5-producing cells in the peripheral tissues, we succeeded to generate IL-5/GFP knock-in mice. IL-5/GFP^+ cells were distributed mainly in the lung and intestinal tissues and they were CD3^- c-kit^- cells but not CD3^+ T cells. We also analyzed RP105 signals in B cell activation and found that RP105 was required for TLR4-dependent plasma cell differentiation and IgM production. Finally, we demonstrated that an interferon-inducible gene Iigp1 had a crucial role in Th1-dependent antigen cross-presentation.
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An adaptor protein Lnk/Sh2B3, negative regulator of lymphohematopoiesis, contributes to the maintenance of gut-associated lymphoid tissues.
接头蛋白 Lnk/Sh2B3 是淋巴造血的负调节因子,有助于维持肠道相关淋巴组织。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Katayama, H.]
通讯作者:
H.
Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokines-and integrin-mediated signals.
Lnk/Sh2b3 接头蛋白通过细胞因子和整合素介导的信号之间的串扰来调节巨核细胞的生长和成熟。
DOI:
--
发表时间:
2008
期刊:
Experimental Hematology Vol.36
影响因子:
--
作者:
[Takizawa H., Takatsu K.]
通讯作者:
Takatsu K.
Identification of soluble MD-1 and its role in autoimmune diseases.
可溶性 MD-1 的鉴定及其在自身免疫性疾病中的作用。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Sasaki, S.]
通讯作者:
S.
The maintenance of gut-associated lymphoid tissues regulated by Lnk/Sh2B3 adaptor, a shared risk factor gene associated with type 1 diabetes and celiac disease
Lnk/Sh2B3 接头调节肠道相关淋巴组织的维持,Lnk/Sh2B3 接头是与 1 型糖尿病和乳糜泻相关的共有危险因素基因
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[片山緩子、井関將典, 他]
通讯作者:
他
DOI:
10.1084/jem.20100900
发表时间:
2011-01-17
期刊:
The Journal of experimental medicine
影响因子:
--
作者:
[Murakami M, Okuyama Y, Ogura H, Asano S, Arima Y, Tsuruoka M, Harada M, Kanamoto M, Sawa Y, Iwakura Y, Takatsu K, Kamimura D, Hirano T]
通讯作者:
Hirano T
共 43 条
Analysis of innate IL-5 producing cells in immune responses and chronic inflammation
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批准号:24390119
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.73万
-
财政年份:2012
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负责人:TAKATSU Kiyoshi
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依托单位:
Spatiotemporal control of allergy and non-infectious inflammation and their regulation by natural products
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批准号:23659247
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2011
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负责人:TAKATSU Kiyoshi
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依托单位:
Enhancement of Th1 and antitumor immunity by Ag85B and Peptide-25.
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批准号:17013024
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$34.24万
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财政年份:2005
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负责人:TAKATSU Kiyoshi
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依托单位:
Investigation of regulatory mechanisms for homeostasis and activation of lymphocyte
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批准号:16109004
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$63.65万
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财政年份:2004
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负责人:TAKATSU Kiyoshi
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依托单位:
REGULATORY MECHANISMS OF IL-5 DEPENDENT IMMUNE REGULATION
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批准号:13307012
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$35.36万
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财政年份:2001
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负责人:TAKATSU Kiyoshi
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依托单位:
Molecular mechanisms of isotype switch recombination.
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批准号:11470083
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$9.22万
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财政年份:1999
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负责人:TAKATSU Kiyoshi
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依托单位:
Molecular mechanisms of oral immunity : Role of IL-5 in potentiation of IgA production in mucosal lymphoid cell
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批准号:10557036
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.36万
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财政年份:1998
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负责人:TAKATSU Kiyoshi
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依托单位:
Molecular mechanisms of proliferation and differentiation of germinal center B cells
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批准号:09470091
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.51万
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财政年份:1997
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负责人:TAKATSU Kiyoshi
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依托单位:
Signaling through surface receptors in immune cells.
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批准号:09044263
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$3.46万
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财政年份:1997
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负责人:TAKATSU Kiyoshi
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依托单位:
Molecular Mechanisms and Intervention of Immunological Diseases.
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批准号:08282101
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$38.46万
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财政年份:1996
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负责人:TAKATSU Kiyoshi
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依托单位:
Signal transduction through cell surface receptors
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批准号:07044225
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$3.71万
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财政年份:1995
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负责人:TAKATSU Kiyoshi
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依托单位:
Mechanism of pathogenesis of chronic inflamation
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批准号:07557030
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$8.32万
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财政年份:1995
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负责人:TAKATSU Kiyoshi
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依托单位:
Studies on the mechanisms of the maturation of germinal center B cells.
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批准号:05404024
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$18.18万
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财政年份:1993
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负责人:TAKATSU Kiyoshi
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依托单位:
MECHANISM OF PATHOGENESIS OF LATE-PHASE ASTHMATIC RESPONSE (LAR) : PREVENTIVE EFFECT OF ANTI-IL-5 ANTIBODY ON LAR IN ANIMAL MODEL
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批准号:05557023
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$8.13万
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财政年份:1993
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负责人:TAKATSU Kiyoshi
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依托单位:
MECHANISMS OF SIGNAL TRANSDUCTION THROUGH SURFACE RECEPTORS
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批准号:04044135
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$5.44万
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财政年份:1992
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负责人:TAKATSU Kiyoshi
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依托单位:
Role of IL-5 and Receptor System in the Regulation of the Immune System and Inflammatory Response.
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批准号:02404033
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$11.39万
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财政年份:1990
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负责人:TAKATSU Kiyoshi
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依托单位:
Regulatory Role of Interleukin 5 and Its Receptor in the Bcell Growth and Differentiation
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批准号:01044115
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$5.57万
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财政年份:1989
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负责人:TAKATSU Kiyoshi
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依托单位:
SIGNAL TRANSDUCTION THROUGH CYTOKINES AND THEIR RECEPTOR FOR B CELL GROWTH AND DIFFERENTIATION
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批准号:63480171
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1988
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负责人:TAKATSU Kiyoshi
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依托单位:
Regulation of B cell growth and differentiation and immune abnormality
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批准号:61480159
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.1万
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财政年份:1986
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负责人:TAKATSU Kiyoshi
-
依托单位:
国内基金
海外基金
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IL-33/IL-5通路介导的2型固有淋巴细胞参与维持心肌细胞自噬-凋亡平衡拮抗脓毒症心肌损伤的作用机制
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批准号:82172153
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TNF-α介导IL-5阴性鼻息肉激素抵抗的分子机制研究
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资助金额:23.0万元
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批准年份:2013
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负责人:孟娟
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联合IL-5可溶性受体及IL-4突变体控制哮喘气道炎症及气道高反应性
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批准号:81070028
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资助金额:32.0万元
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批准年份:2010
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负责人:李志奎
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新型海洋环肽类IL-5抑制剂的合成与结构优化
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资助金额:21.0万元
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批准年份:2010
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负责人:张伟
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重组IL-5及IL-13可溶性受体控制哮喘气道嗜酸细胞炎症及气道高反应性研究
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批准号:30770926
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JAK2调控IL-5/IL-5R信号转导的分子机制
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批准号:30700736
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资助金额:15.0万元
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批准年份:2007
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负责人:谭政
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染色质重塑和可逆乙酰化修饰在白细胞介素5(IL-5)基因转录调控中的作用机制研究
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批准号:30571698
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异种IL-5 DNA疫苗主动免疫基因治疗哮喘的实验研究
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资助金额:19.0万元
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IL-5对TGFβ基因表达调控及在慢性移植排斥中的作用
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治喘贴促进哮喘机体Eos凋亡、对Eos、IL-5的调节作用
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