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Detection of HMGB1 in acetaminophen-induced liver injury model and its application for forensic diagnosis

Detection of HMGB1 in acetaminophen-induced liver injury model and its application for forensic diagnosis
对乙酰氨基酚肝损伤模型中HMGB1的检测及其在法医学诊断中的应用
批准号：
23659370
负责人：
ISHIDA Yuko
金额：
$2.41万
依托单位：
Wakayama Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659370/
关键词：
HMGB1アセトアミノフェン法医診断学

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中文摘要
翻译
我们检测了HMGB1在对乙酰氨基酚(APAP)诱导的肝损伤中的表达。注射APAP的小鼠肝脏HMGB1mRNA表达增强。正常肝组织HMGB1蛋白定位于肝细胞核内，APAP攻击后肝细胞胞浆内可见HMGB1蛋白表达。肝组织中HMGB1的检测可作为APAP致肝损伤的尸检诊断工具。
英文摘要
We examined HMGB1 expression in acetaminophen (APAP)-induced liver injury. mRNA expression of HMGB1 was enhanced in the liver of mice injected with APAP. Although HMGB1 protein was detected in hepatocyte nuclei of normal liver, it was observed in cytoplasm of hepatocytes after APAP challenge. The detection of HMGB1 in the liver could be considered as valuable diagnostic tools for the postmortem diagnosis of APAP-induced liver injury.
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  • 批准号：
    20689015
  • 项目类别：
    Grant-in-Aid for Young Scientists (A)
  • 资助金额：
    $16.56万
  • 财政年份：
    2008
  • 负责人：
    ISHIDA Yuko
  • 依托单位：
    Wakayama Medical University
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