Examination of chemokine roles in CLP-induced sepsis model and its application for forensic diagnosis

我们检测了CCR2和CX3CR1在脓毒症所致肺损伤中的表达。形态计量学双色免疫荧光分析显示，脓毒症组CCR2和CX3CR1阳性巨噬细胞平均数明显高于对照组。免疫组织化学检测肺组织中CCR2和CX3CR1的表达可作为身体诊断脓毒症的有价值的工具。

We examined CCR2 and CX3CR1 expression in sepsis-induced lung injury. Morphometrically, the average of CCR2-and CX3CR1-positive macrophages was significantly increased in sepsis group compared with control group in double-color immunofluorescence analysis. Immunohistochemical detection of CCR2 and CX3CR1 expression in the lungs can be considered as valuable diagnostic tools for the postmortem diagnosis of sepsis.