Pathophysiology of myelodyspoastic syndrome - network between bone marrow and nervus system

在正常人骨髓中，表达巢蛋白的细胞呈梭形，与内皮细胞不同，是构成血管壁的细胞。相比之下，这种结构在骨髓发育不良综合征患者的骨髓中被打乱。我们进一步发现，在表达Nestin的细胞中Notch信号被敲除的小鼠胎肝造血功能异常，暗示Notch信号在表达Nestin的基质细胞中在造血中发挥重要作用。

In normal human bone marrow, spindle-shaped nestin-expressing cells, distinct from endothelial cells, were shown as the vascular vessel wall-constituting cells. In contrast, such a structure was disarranged in the bone marrow of myelodyspoastic syndrome patients. We further found abnormalities in fetal liver hematopoiesis in mice with knocked-down Notch signaling in cells expressing nestin, implying important roles of Notch signaling in nestin-expressing stromal cells in hematopoiesis.