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Establishment of the new concept "pathogenic mechanism of periodontal disease by the induction of senescence of the tissues".

Establishment of the new concept "pathogenic mechanism of periodontal disease by the induction of senescence of the tissues".
建立“诱导组织衰老导致牙周病发病机制”新概念。
批准号:
23659974
负责人:
YAMAZAKI Kazuhisa
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

项目摘要

项目成果

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中文摘要
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英文摘要
Endoplasmic reticulum stress was induced in gingival tissue of orally periodontopathic bacterium infected mice. Administration of chemical chaperone,4-phenylbutyric acid, significantly inhibited alveolar bone resorption in the infected mice. In addition, 4-phenylbutyric acid inhibited osteoclastogenesis in vitro. Our findings suggest that endoplasmic reticulum stress involves osteoclastogenesis during alveolar bone resorption in the progression of periodontal disease.
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会议论文
Up-regulation of Endoplasmic Reticulum Stress Response in Mouse Periodontitis Model
小鼠牙周炎模型中内质网应激反应的上调
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Miyazawa H, Domon H, et al, Domon H]
通讯作者: Domon H
DOI: 10.1016/j.cca.2011.09.023
发表时间: 2012-01-18
期刊: CLINICA CHIMICA ACTA
影响因子: 5
作者: [Miyazawa, Haruna, Honda, Tomoyuki, Yamazaki, Kazuhisa]
通讯作者: Yamazaki, Kazuhisa
5疾病の口腔ケア
口腔护理5种疾病
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Miyauchi S, Yamazaki K et al., 土門久哲(山崎和久), Hisanori Domon (Kazuhisa Yamazaki), 山崎和久,中島貴子, 山崎和久, 山崎和久,中島貴子]
通讯作者: 山崎和久,中島貴子
ビジュアル 歯周病を科学する
牙周病的视觉科学
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kuboniwa M, Amano A(In de Filipis I, McKee ML (ed.)), 天野敦雄(天野敦雄,村上伸也,岡賢二編), 天野敦雄(天野敦雄,村上伸也,岡賢二編), 天野敦雄(天野敦雄,村上伸也,岡賢二編), 天野敦雄(水島昇・吉森保編), 天野敦雄, 天野敦雄]
通讯作者: 天野敦雄
13
    New hypothesis for the pathogenesis of periodontal medicine
    • 批准号:
      25670882
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2013
    • 负责人:
      YAMAZAKI Kazuhisa
    • 依托单位:
    Analysis of the pathway from periodontal disease to lipid metabolism perturbation
    • 批准号:
      23390476
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.23万
    • 财政年份:
      2011
    • 负责人:
      YAMAZAKI Kazuhisa
    • 依托单位:
    Clarification of the pathogenicity of periodontal disease involving exacerbation of metabolic syndrome ; an approach based on immunological characteristics.
    • 批准号:
      19390536
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.98万
    • 财政年份:
      2007
    • 负责人:
      YAMAZAKI Kazuhisa
    • 依托单位:
    Clarification of the mechanisms for connective tissue destruction and alveolar bone resorption in periodontal disease by comprehensive analysis of infiltrating T cells using immunological and molecular biological techniques
    • 批准号:
      16390613
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.09万
    • 财政年份:
      2004
    • 负责人:
      YAMAZAKI Kazuhisa
    • 依托单位:
    海外基金