Recognition mechanism of DNA by innate immunity

先天免疫对DNA的识别机制

• 批准号: 23689030
• 负责人: KAWAI Taro
• 金额: $ 17.56万
• 依托单位: Nara Institute of Science and Technology (2013)Osaka University (2011-2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23689030/
• 关键词: 自然免疫; DNAセンサー; シグナル伝達; インターフェロン; ウイルス; 自己免疫疾患; ウイルス感染

Upon recognition of double-stranded DNA derived from virus or bacteria by innate immunity, host cells produce type I interferon or other inflammatory mediators essential for host defense. However, mechanisms involved in DNA recognition are unclear. In addition, it is suggested that self-DNA derived from damaged cells are recognized by innate immunity and this is considered to be responsible for development of inflammatory and autoimmune diseases. In this research, we identified MRE11, a protein involved in repair responses, as a candidate protein involved in self-DNA recognition and induction of type I interferon and inflammatory cytokines. MRE11 binds to and colocalizes with immunostimulatory DNA, and cells that do not express MRE11 have defects in induction of these cytokines by immunostimulatory DNA. These findings may shed light on our understanding of pathogenesis of autoimmunity in which aberrant DNA recognition is involved.

在识别由先天免疫衍生自病毒或细菌的双链DNA后，宿主细胞会产生I型干扰素或其他对于宿主防御所必需的炎症介质。但是，涉及DNA识别的机制尚不清楚。此外，建议从损坏的细胞中得出的自DNA被先天免疫认识到，这被认为是造成炎症和自身免疫性疾病的原因。在这项研究中，我们确定了一种参与修复反应的蛋白质的MRE11，是一种参与自DNA识别和I型干扰素和炎症细胞因子的候选蛋白质。 MRE11与免疫刺激性DNA结合并共定位，未表达MRE11的细胞通过免疫刺激DNA诱导这些细胞因子有缺陷。这些发现可能会阐明我们对自身免疫的发病机理的理解，其中涉及异常DNA识别。

项目成果

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

• DOI: 10.1016/j.immuni.2011.05.006
• 发表时间: 2011-05-27
• 期刊: IMMUNITY
• 影响因子: 32.4
• 作者: Kawai, Taro;Akira, Shizuo
• 通讯作者: Akira, Shizuo

免疫学Update

免疫学更新

• 发表时间: 2012
• 作者: 香山尚子;竹田潔
• 通讯作者: 竹田潔

Poly ICのアジュバント効果における細胞死の役割

细胞死亡在 Poly IC 佐剂作用中的作用

• 发表时间: 2013
• 作者: 金田典雄;伊東進 編;河合太郎
• 通讯作者: 河合太郎

The Second Messenger Phosphatidylinositol-5-Phosphate Facilitates Antiviral Innate Immune Signaling

• DOI: 10.1016/j.chom.2013.07.011
• 发表时间: 2013-08-14
• 期刊: CELL HOST & MICROBE
• 影响因子: 30.3
• 作者: Kawasaki, Takumi;Takemura, Naoki;Kawai, Taro
• 通讯作者: Kawai, Taro

Dissection of signaling pathways through innate receptors that sense foreign nucleic acids

通过感知外源核酸的先天受体剖析信号通路

• 发表时间: 2011
• 作者: 近藤科江;他;Taro Kawai
• 通讯作者: Taro Kawai