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Corneal regeneration using epithelial, stromal, and endothelial precursor cells based on epigenetical control.

Corneal regeneration using epithelial, stromal, and endothelial precursor cells based on epigenetical control.
基于表观遗传控制,使用上皮、基质和内皮前体细胞进行角膜再生。
批准号:
23689072
负责人:
MIMURA Tatsuya
金额:
$17.47万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (A)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31

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中文摘要
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英文摘要
We examined cellular aging and epigenetical alteration in corneal cells. We obtaiined corneal cells from endothelium, stoma, and epithelum of various aged donor corneas. Additionally, we obtained progenitor cells from each corneal cell layer by sphere-forming assay. By comparing the methylation among donor age, we found the ratio of methylation was higher in the cell from oleder donor cornea compared with younger donor conreas.
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DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Mimura T, Tabata Y, Amano S]
通讯作者: Amano S
DOI: 10.1186/1471-2415-11-29
发表时间: 2011-09-26
期刊: BMC ophthalmology
影响因子: 2
作者: [Noma H, Funatsu H, Mimura T, Shimada K]
通讯作者: Shimada K
Development of surgical treatment for vitreous disease
玻璃体疾病手术治疗的进展
DOI: --
发表时间: 2012
期刊: Surgical Science
影响因子: --
作者: [Mimura T, Noma H, Funatsu H]
通讯作者: Funatsu H
Corneal endothelial tissue bioengineering using cultured human corneal endothelial precursor cells(In : Jose A. Andrades, editor. Chapter 18, Regenerative Medicine and Tissue Engineering)(ISBN 978-953-51-1108-5)
使用培养的人角膜内皮前体细胞进行角膜内皮组织生物工程(见:Jose A. Andrades,编辑。第18章,再生医学和组织工程)(ISBN 978-953-51-1108-5)
DOI: --
发表时间:
期刊:
影响因子: --
作者: [Mimura T, Yokoo S, Yamagami S]
通讯作者: Yamagami S
80
    Autologous transplantation of conjunctival epithelial stem cells based on epigenetical control.
    • 批准号:
      24659757
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2012
    • 负责人:
      MIMURA Tatsuya
    • 依托单位:
    Autologous transplantation of conjunctival epithelial stem cells
    Corneal regeneration using epithelial, stromal, and endothelial precursor cells based on cellular senescence control
    • 批准号:
      20689032
    • 项目类别:
      Grant-in-Aid for Young Scientists (A)
    • 资助金额:
      $15.64万
    • 财政年份:
      2008
    • 负责人:
      MIMURA Tatsuya
    • 依托单位:
    海外基金