Molecular mechanisms of target recognition and subcellular specificity in developing nervous system

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The amygdaloid complex is a principal component of the limbic system with important roles in emotion and fear memory. During development, axons of distinct amygdaloid nuclei project to different parts of the bed nucleus of the stria terminalis (BNST). However, it remains largely unknown how these connections are formed during development. Here, we examined the role of axon guidance molecule semaphorins and their receptor plexins in the formation of the amygdala-BNST network, and found that Sema6A/plexin-A4 signaling regulates the precise connectivity between the distinct amygdala projection neurons and their targets in the BNST.