Identification of target molecules against anti MuSK IgG in Myasthenia Gravis

重症肌无力抗 MuSK IgG 靶分子的鉴定

• 批准号: 23700422
• 负责人: ITO Mikako
• 金额: $ 2.83万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700422/
• 关键词: 重症筋無力症; MuSK; Collagen Q; LRP4; 筋・末梢神経疾患; 国際研究者交流; パリ; アセチルコリンエステラーゼ

Myasthenia Gravis (MG) is antoimmuno disease caused by an antoantibody to protein consisting of neuromuscular junction. Anti MuSK MG account for fifteen percent of MG ,but it is unclear well. MuSK is membrane transfer protein of NMJ, and has Ig1, Ig2, Ig3, Ig4 and C6 box in extracellar region. In this study, it was demonstrated that anti-MuSK antibody from five persons inhibit both MuSK-ColQ and MuSK-LRP4 interaction. Moreover, MuSK antibody recognizes Ig1 and Ig4, and LRP4 also binds Ig1 and Ig4.

重症肌无力(MG)是由神经肌肉连接蛋白自身抗体引起的自身免疫性疾病。反马斯克MG占MG的15%，但还不清楚。麝香是NMJ的膜转移蛋白，胞外区含有IG1、IG2、IG3、IG4和C6盒。在这项研究中，来自五个人的抗麝香抗体同时抑制了麝香-ColQ和穆斯克-LRP4的相互作用。此外，麝香抗体识别免疫球蛋白1和免疫球蛋白4，LRP4也结合免疫球蛋白1和免疫球蛋白4。

项目成果

Congenital Myasthenic Syndromes . Molecular Bases of Congenital Defects of Proteins at the Neuromuscular Junction

先天性肌无力综合症。

• 发表时间: 2012
• 作者: Kinji Ohno;Mikako Ito;Andrew G. Engel
• 通讯作者: Andrew G. Engel

CUGBP1 and MBNL1 preferentially bind to 3' UTRs and facilitate mRNA decay.

• DOI: 10.1038/srep00209
• 发表时间: 2012
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Masuda A;Andersen HS;Doktor TK;Okamoto T;Ito M;Andresen BS;Ohno K
• 通讯作者: Ohno K

Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease

• DOI: 10.1016/j.parkreldis.2010.11.004
• 发表时间: 2011-01-01
• 期刊: PARKINSONISM & RELATED DISORDERS
• 影响因子: 4.1
• 作者: Hirayama, Masaaki;Nakamura, Tomohiko;Sobue, Gen
• 通讯作者: Sobue, Gen

Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies.

• DOI: 10.1186/2045-9912-1-24
• 发表时间: 2011-10-03
• 期刊: Medical gas research
• 影响因子: 2.9
• 作者: Ito M;Ibi T;Sahashi K;Ichihara M;Ito M;Ohno K
• 通讯作者: Ohno K

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage by in utero ischemia-reperfusion.

母体分子氢给药可改善子宫内缺血再灌注引起的大鼠胎儿海马损伤。

• 发表时间: 2014
• 期刊: Free Radic. Biol. Med.
• 作者: Mano;Y.;Kotani;T.;Ito;M.;Nagai;T.;Ichinohashi;Y.;Yamada;K.;Ohno;K.;Kikkawa;F. and Toyokuni;S.
• 通讯作者: S.