Functional significance of microtubuledynamics controlled counteractively by cAMP and cGMP

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During development, neurons extend axons to make connections with the targets. The growth cone at the tip of the elongating axon senses guidance cues in the extracellular environment and thus plays a central role in establishing the proper connections. Elucidating intracellular events mediating growth cone steering is essential for understanding the basis of neuronal circuit assembly. In this project, I showed that cyclic nucleotides mediate axon guidance by regulating microtubule-dependent vesicle transport in the growth cones.