Slitrk5 knock-out mice showed elevated anxiety and depression like behavior.

Slitrk家族与精神障碍或听觉功能密切相关。然而，Slitrk5函数还不为人所知。为此，我们培育了Slitrk5基因敲除(KO)小鼠，并进行了全面的行为学测试。Slitrk5KO小鼠表现出焦虑和抑郁样行为增加，海马区各脑区5-羟色胺水平显著降低。综上所述，Slitrk5与焦虑和抑郁障碍的发病机制密切相关，其机制是通过损害海马区的5-羟色胺浓度。

Slitrk family is strongly associated with the psychiatric disorder or auditory function. However, Slitrk5 function has not been known yet. We therefor generated Slitrk5 knockout (KO) mouse and performed comprehensive behavioral tests. Slitrk5 KO mice showed the increased anxiety and depression like behavior, and moreover showed significantly decreased serotonin levels in hippocampus among various brain regions. Taken together with these results, Slitrk5 is strongly associated with pathogenesis of anxiety and depression disorder through impairment of serotonin concentration in hippocampus.