Slitrk5 knock-out mice showed elevated anxiety and depression like behavior.

Slitrk5 敲除小鼠表现出焦虑和抑郁样行为升高。

• 批准号: 23700457
• 负责人: MATSUMOTO Yoshifumi
• 金额: $ 2.66万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700457/
• 关键词: SLITRK; 不安障害; 気分障害; Slitrkファミリー; 神経; LRR; SLITRKファミリー; 海馬; シナプトジェネシス

Slitrk family is strongly associated with the psychiatric disorder or auditory function. However, Slitrk5 function has not been known yet. We therefor generated Slitrk5 knockout (KO) mouse and performed comprehensive behavioral tests. Slitrk5 KO mice showed the increased anxiety and depression like behavior, and moreover showed significantly decreased serotonin levels in hippocampus among various brain regions. Taken together with these results, Slitrk5 is strongly associated with pathogenesis of anxiety and depression disorder through impairment of serotonin concentration in hippocampus.

Slitrk家族与精神障碍或听觉功能密切相关。但是，尚未知道slitrk5函数。因此，我们生成了SLITRK5敲除（KO）小鼠并进行了全面的行为测试。 slitrk5 ko小鼠表现出焦虑和抑郁症等行为的增加，而且在各个大脑区域中，海马中的5-羟色胺水平显着降低。与这些结果结合在一起，通过海马中5-羟色胺浓度损害，SLITRK5与焦虑和抑郁症的发病机理密切相关。

项目成果

3 SLITRK6 mutations cause myopia and deafness in humans and mice

3 SLITRK6突变导致人类和小鼠近视和耳聋

• 发表时间: 2013
• 期刊: The Journal of Clinical Investigation 2013
• 作者: Mustafa Tekin;Barry A. Chioza;Yoshifumi Matsumoto;Oscar Diaz-Horta;Harold E. Cross;Duygu Duman;Haris Kokotas;Heather L. Moore-Barton;Kazuto Sakoori;Maya Ota;Yuri S. Odaka;Joseph Foster II;F. Basak Cengiz;Suna Tokgoz-Yilmaz;Oya Tekeli;Maria
• 通讯作者: Maria

Selective control of inhibitory synapse development by Slitrk3-PTP・trans-synaptic interaction

通过 Slitrk3-PTP·跨突触相互作用选择性控制抑制性突触发育

• 发表时间: 2012
• 期刊: Nat Neurosci
• 影响因子: 25
• 作者: Takahashi H.;Katayama K.;Sohya K.;Miyamoto H.;Prasad T.;Matsumoto Y.;Ota M.;Yasuda H.;Tsumoto T.;Aruga J and Craig AM
• 通讯作者: Aruga J and Craig AM

Slitrk6欠損マウスの聴覚および前庭機能異常について

Slitrk6缺陷小鼠的听力和前庭功能异常

• 发表时间: 2011
• 作者: Abe K;Takahashi T;Takikawa Y;Arai H;Kitazawa S;松本圭史
• 通讯作者: 松本圭史

Zic2 knock down mice show the higher response to auditory stimulus and size reduction of DCoN

Zic2 敲低小鼠对听觉刺激和 DCoN 尺寸减小表现出更高的反应

• 发表时间: 2011
• 作者: Matsumoto Y.;Takashima N.;Nozaki Y.;Nishioka C.;Kudoh M.;and Aruga J.
• 通讯作者: and Aruga J.

LRRシナプスオーガナイザーと神経疾患

LRR突触组织者与神经系统疾病

• 发表时间: 2012
• 期刊: 実験医学
• 作者: 有賀純;松本圭史
• 通讯作者: 松本圭史