Physiological genetics of primary sensory neurons

我们发现E3泛素连接酶无名指蛋白121是机械接受的重要基因。我们还发现该基因对电压门控钠通道功能至关重要。缺乏无名指蛋白121的斑马鱼胚胎对触觉刺激和芥菜油都没有反应，从而证明无名指蛋白121对于动物生存所必需的机械接收和化学接收是必不可少的。

We identified an E3 ubiquitin ligase ring finger protein 121 as an essential gene for mechanoreception. We also revealed that this gene is essential for voltage-gated sodium channel function. Zebrafish embryos that lack the ring finger protein 121 did not respond to either tactile stimulus or mustard oil, thereby demonstrating that the ring finger protein 121 is indispensable for mechanoreception and chemical reception, which are essential for survival of animals.