Physiological genetics of primary sensory neurons

初级感觉神经元的生理遗传学

• 批准号: 23700477
• 负责人: HIRATA Hiromi
• 金额: $ 2.83万
• 依托单位: National Institute of Genetics
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700477/
• 关键词: 体性感覚; 感覚ニューロン

We identified an E3 ubiquitin ligase ring finger protein 121 as an essential gene for mechanoreception. We also revealed that this gene is essential for voltage-gated sodium channel function. Zebrafish embryos that lack the ring finger protein 121 did not respond to either tactile stimulus or mustard oil, thereby demonstrating that the ring finger protein 121 is indispensable for mechanoreception and chemical reception, which are essential for survival of animals.

我们确定了E3遍在蛋白连接酶环指蛋白121作为机械感受的必需基因。我们还发现，该基因是电压门控钠通道功能所必需的。缺乏无名指蛋白121的斑马鱼胚胎对触觉刺激或芥子油都没有反应，从而证明无名指蛋白121对于动物生存所必需的机械感受和化学感受是不可或缺的。

项目成果

Formation and function of glycinergic synapse in zebrafish

斑马鱼甘氨酸突触的形成和功能

• 发表时间: 2013
• 作者: Hirata;H
• 通讯作者: H

グリシン受容体の構造と機能

甘氨酸受体的结构和功能

• 发表时间: 2012
• 作者: 佐野裕美;知見聡美;小林和人;南部篤;平田普三
• 通讯作者: 平田普三

The biological role of the glycinergic synapse in early zebrafish motility

• DOI: 10.1016/j.neures.2011.06.003
• 发表时间: 2011-09-01
• 期刊: NEUROSCIENCE RESEARCH
• 影响因子: 2.9
• 作者: Hirata, Hiromi;Takahashi, Megumi;Ogino, Kazutoyo
• 通讯作者: Ogino, Kazutoyo

Developmental transition of touch response from slow muscle-mediated coilings to fast muscle-mediated burst swimming in zebrafish

• DOI: 10.1016/j.ydbio.2011.04.027
• 发表时间: 2011-07-15
• 期刊: DEVELOPMENTAL BIOLOGY
• 影响因子: 2.7
• 作者: Naganawa, Yuriko;Hirata, Hiromi
• 通讯作者: Hirata, Hiromi

Slow-twitch and fast-twitch muscle defects in zebrafish

斑马鱼的慢肌和快肌缺陷

• 发表时间: 2012
• 作者: Hirata;H.
• 通讯作者: H.