Functional analysis of transcription factor Bach1 for oncogenic Ras in vivo

体内致癌Ras转录因子Bach1的功能分析

• 批准号: 23701066
• 负责人: SAKAHARA Mizuho
• 金额: $ 2.83万
• 依托单位: Japanese Foundation For Cancer Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23701066/
• 关键词: Ras発がん; Bach1; 皮膚扁平上皮がん; 膵臓がん; マウス

The incidence of skin squamous cell carcinoma (SCC) induced by activation of oncogenic Ras is affected by polymorphism of patched (ptch) gene in mice (C57BL/6 strain: resistance, FVB strain: high susceptibility). In this study, we obtained K5-Hras transgenic mice of C57BL/6 background which carry ptch allele of FVB strain (K5-Hras Tg; ptchFVB/FVB). Our results suggest that the SCC formation is promoted K5-Hras Tg; ptchFVB/FVB mice as compared with the K5-Hras Tg; ptchB6/FVB mice. However, the tumor latency in the model system of these mice was not affected by loss of Bach1

小鼠patched（ptch）基因多态性（C57 BL/6品系：耐药，FVB品系：高敏感）影响致癌基因Ras激活诱发的皮肤鳞状细胞癌（SCC）的发生。本研究获得了携带FVB株ptch等位基因的C57 BL/6背景K5-Hras转基因小鼠（K5-Hras Tg; ptchFVB/FVB）。我们的结果表明，与K5-Hras Tg; ptchB 6/FVB小鼠相比，K5-Hras Tg; ptchFVB/FVB小鼠的SCC形成更快。然而，这些小鼠模型系统中的肿瘤潜伏期不受Bach 1缺失的影响