Functional analysis of transcription factor Bach1 for oncogenic Ras in vivo

致癌Ras激活诱导小鼠皮肤鳞状细胞癌（SCC）的发生受斑块（ptch）基因多态性（C57BL/6株：抗性，FVB株：高敏感）的影响。本研究获得了C57BL/6背景的K5-Hras转基因小鼠，其携带FVB菌株的ptch等位基因（K5-Hras Tg; ptchFVB/FVB）。我们的结果表明，K5-Hras Tg促进了SCC的形成；ptchFVB/FVB小鼠与K5-Hras Tg比较；ptchB6 / FVB老鼠。然而，这些小鼠模型系统中的肿瘤潜伏期不受Bach1缺失的影响

The incidence of skin squamous cell carcinoma (SCC) induced by activation of oncogenic Ras is affected by polymorphism of patched (ptch) gene in mice (C57BL/6 strain: resistance, FVB strain: high susceptibility). In this study, we obtained K5-Hras transgenic mice of C57BL/6 background which carry ptch allele of FVB strain (K5-Hras Tg; ptchFVB/FVB). Our results suggest that the SCC formation is promoted K5-Hras Tg; ptchFVB/FVB mice as compared with the K5-Hras Tg; ptchB6/FVB mice. However, the tumor latency in the model system of these mice was not affected by loss of Bach1