Phenotypic and genotypic features of radiation-induced mammary cancer and insights into its cell of origin

辐射诱发乳腺癌的表型和基因型特征及其细胞起源的见解

• 批准号: 23710074
• 负责人: IMAOKA Tatsuhiko
• 金额: $ 2.91万
• 依托单位: National Institute of Radiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23710074/
• 关键词: 生物影響; 放射線発がん; in vivo実験; 起源細胞; 乳がん; 単回照射

It is unclear whether radiation-induced breast cancer shows specific phenotypic and genotypic features and originates from cells at a specific differentiation stage. We evaluated the associations between genetic and phenotypic features of spontaneous, radiation-induced and chemically-induced rat mammary cancers. We revealed that clustering analyses of immunohistochemical and microarray-based gene expression profile data classified the cancers into several subtypes. Radiation-induced cancers were overrepresented in a specific subtype, which developed earlier than others. As this subtype has been reported to originate from a specific progenitor cell in humans and mice, the present results suggest that radiation-induced rat mammary cancer initiates in cells at a specific differentiation stage.

目前尚不清楚辐射诱导的乳腺癌是否显示特定的表型和基因型特征，并且起源于特定分化阶段的细胞。我们评估了自发，辐射诱导和化学诱导的大鼠乳腺癌的遗传和表型特征之间的关联。我们揭示了对基于免疫组织化学和微阵列的基因表达谱数据的聚类分析将癌症分类为几种亚型。辐射引起的癌症的特定亚型比其他亚型的癌症过多。由于据报道该亚型起源于人类和小鼠的特定祖细胞，因此目前的结果表明，辐射诱导的大鼠乳腺癌在特定分化阶段会在细胞中启动。

项目成果

長期低線量率被ばく状況における乳がん誘発影響の蓄積性とその機構

长期低剂量率暴露情况下乳腺癌诱发效应的累积性质和机制

• 发表时间: 2012
• 期刊: 放射線生物研究
• 作者: 今岡達彦;細木彩夏;臺野和広;高畠賢;西村まゆみ;島田義也
• 通讯作者: 島田義也

低線量率被ばくと高線量率被ばくが引き起こす生物影響に対する分子・細胞生物学的アプローチ：個体における放射線発がんメカニズム研究からのアプローチ

低剂量率和高剂量率照射引起的生物效应的分子和细胞生物学方法：个体辐射致癌机制研究的方法

• 发表时间: 2013
• 作者: 今岡 達彦; 西村 まゆみ; 臺野 和広; 細木 彩夏; 高畠 賢; ショウラー 恵; 飯塚 大輔; 島田 義也
• 通讯作者: 島田 義也

Progesterone stimulates proliferation of a long-lived epithelial cell population in rat mammary gland

黄体酮刺激大鼠乳腺中长寿上皮细胞群的增殖

• 发表时间: 2012
• 期刊: J Endocrinol Invest
• 影响因子: 5.4
• 作者: Tatsuhiko Imaoka;Hiromi Hisatune;Yoshimi Sakanishi;Yukiko Nishimura;Mayumi Nishimura;Yoshiya Shimada
• 通讯作者: Yoshiya Shimada

Combined exposure to multiple carcinogens enhances development of rat mammary cancers with characteristic gene expression

联合暴露于多种致癌物可促进具有特征性基因表达的大鼠乳腺癌的发展

• 发表时间: 2012
• 作者: Tatsuhiko Imaoka;Mayumi Nishimura;Kenichi Ishikawa;Satoshi Yamashita;Yasushi Ohmachi;Hideyuki Suzuki;Kazuhiro Daino;Toshikazu Ushijima;Takashi Imai;Yoshiya Shimada
• 通讯作者: Yoshiya Shimada

Mammary carcinogenesis after exposure of ...

接触...后乳腺癌发生

• 作者: Ochiai H;Fujita K;Nishikawa M;Suzuki K;Matsuura S;Miyamoto T;Sakuma T;Sakamoto N;Shibata T;Yamamoto T;Imaoka T et al.
• 通讯作者: Imaoka T et al.