Preparation of functional hydrogels composed of filamentous viruses

丝状病毒功能性水凝胶的制备

• 批准号: 23710122
• 负责人: SAWADA Toshiki
• 金额: $ 2.83万
• 依托单位: Tokyo Institute of Technology (2012-2013)The University of Tokyo (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23710122/
• 关键词: 生体関連高分子科学; 生物有機化学; ソフトマテリアル; バイオテクノロジー; 生体関連高分子化学

For the preparation of functional hydrogels composed of filamentous viruses, genetically engineered M13 bacteriophages (phages) and surface-modified gold nanoparticles (GNPs) were utilized. After mixing of the components under the suitable concentration condition, the mixed solutions were self-assembled into hydrogels. The phages and the GNPs in the hydrogels formed lyotropic liquid crystals and well-ordered fractal like network structures, respectively. Furthermore, it was found that mechanical strengths of the viral hydrogels were dependent on the specific molecular interactions between the phages and the GNPs. Furthermore, the hydrogels showed various functions such as self-repairing capabilities and responsiveness for existence of Escherichia coli.

为了制备由丝状病毒组成的功能性水凝胶，利用了基因工程改造的M13噬菌体（M13）和表面修饰的金纳米颗粒（GNP）。在合适的浓度条件下混合组分后，混合溶液自组装成水凝胶。水凝胶中的纳米粒子和纳米颗粒分别形成溶致液晶和有序的分形网络结构。此外，发现病毒水凝胶的机械强度依赖于病毒载体和GNP之间的特定分子相互作用。此外，水凝胶显示出多种功能，如自修复能力和对大肠杆菌存在的响应性。

项目成果

Construction of organic-inorganic hybrid materials composed of gold nanoparticles and filamentous viruses

金纳米粒子与丝状病毒有机-无机杂化材料的构建

• 发表时间: 2012
• 作者: Toshiki Sawada;Naoto Shirakawa;Takeshi Serizawa
• 通讯作者: Takeshi Serizawa

金ナノ粒子と繊維状ウイルスによる分子超構造体の設計と評価

使用金纳米粒子和丝状病毒的分子超结构的设计和评估

• 发表时间: 2012
• 作者: S. Taira(Corresponding);D. Kaneko;K. Onuma;A;Miyazato;T. Hiroki;Y. Konishi-Kawamura;Y. Ichiyanagi;長井拓郎;澤田敏樹・白川直斗・芹澤武
• 通讯作者: 澤田敏樹・白川直斗・芹澤武

Construction of hydrogel composed of superstructured nanoparticle and filamentous virus

超结构纳米颗粒和丝状病毒组成的水凝胶的构建

• 发表时间: 2012
• 作者: Toshiki Sawada;Takeshi Serizawa
• 通讯作者: Takeshi Serizawa

Development of molecular superstructure composed of gold nanoparticle and filamentous virus

金纳米粒子和丝状病毒组成的分子超结构的开发

• 发表时间: 2012
• 作者: Toshiki Sawada;Takeshi Serizawa
• 通讯作者: Takeshi Serizawa

繊維状ウイルスおよび金ナノ粒子からなるメゾスケール集合体の構築と特性評価

由丝状病毒和金纳米颗粒组成的介观组装体的构建和表征

• 发表时间: 2013
• 作者: Alibi Baitukha;Shinsuke Mori;MasaakiSuzuki;澤田敏樹・陳ファンファン・白川直斗・芹澤武
• 通讯作者: 澤田敏樹・陳ファンファン・白川直斗・芹澤武