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Analysis of molecular mechanism of cohesin acetylation by ESCO1 and ESC02

Analysis of molecular mechanism of cohesin acetylation by ESCO1 and ESC02
ESCO1和ESC02对粘连蛋白乙酰化的分子机制分析
批准号:
23710213
负责人:
BANDO Masashige
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
We found that Esco1 acetylates cohesin through its N-terminalinteraction with Pds5. ChIP-seq analysis of ESCO1 showed that it co-localizes with cohesinthroughout the cell cycle. On the other hand acetylation of cohesin by ESCO2 requires Mcmhelicases. Thus Esco2 in human, just like Eco1 in yeast, seems to establish sisterchromatids cohesion during DNA replication progression
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DOI: 10.1038/nature11316
发表时间: 2012-09-13
期刊: NATURE
影响因子: 64.8
作者: [Deardorff, Matthew A., Bando, Masashige, Nakato, Ryuichiro, Watrin, Erwan, Itoh, Takehiko, Minamino, Masashi, Saitoh, Katsuya, Komata, Makiko, Katou, Yuki, Clark, Dinah, Cole, Kathryn E., De Baere, Elfride, Decroos, Christophe, Di Donato, Nataliya, Ernst, Sarah, Francey, Lauren J., Gyftodimou, Yolanda, Hirashima, Kyotaro, Hullings, Melanie, Ishikawa, Yuuichi, Jaulin, Christian, Kaur, Maninder, Kiyono, Tohru, Lombardi, Patrick M., Magnaghi-Jaulin, Laura, Mortier, Geert R., Nozaki, Naohito, Petersen, Michael B., Seimiya, Hiroyuki, Siu, Victoria M., Suzuki, Yutaka, Takagaki, Kentaro, Wilde, Jonathan J., Willems, Patrick J., Prigent, Claude, Gillessen-Kaesbach, Gabriele, Christianson, David W., Kaiser, Frank J., Jackson, Laird G., Hirota, Toru, Krantz, Ian D., Shirahige, Katsuhiko]
通讯作者: Shirahige, Katsuhiko
Lombardi PM,Magnaghi-Jaulin L, Mortier GR, Nozaki N, Petersen MB, Seimiya H, Siu VM, Suzuki Y, Takagaki K, Wilde JJ, Willems PJ, Prigent C, Gillessen-Kaesbach G, Christianson DW, Kaiser FJ, Jackson LG, Hirota T,Krantz ID
Lombardi PM、Magnaghi-Jaulin L、Mortier GR、Nozaki N、Petersen MB、Seimiya H、Siu VM、Suzuki Y、Takagaki K、Wilde JJ、Willems PJ、Prigent C、Gillessen-Kaesbach G、Christianson DW、Kaiser FJ、Jackson
DOI: --
发表时间: 2012
期刊: Shirahige K..,HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle., Nature.
影响因子: --
作者: [Deardorff MA, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, Saitoh K, Komata M, Katou Y, Clark D, Cole KE, De Baere E, Decroos C, Di Donato N, Ernst S, Francey LJ, Gyftodimou Y, Hirashima K, Hullings M, Ishikawa Y, Jaulin C, Kaur M, Kiyono T]
通讯作者: Kiyono T
DOI: 10.1021/jm300837y
发表时间: 2012-11-22
期刊: JOURNAL OF MEDICINAL CHEMISTRY
影响因子: 7.3
作者: [Suzuki, Takayoshi, Ota, Yosuke, Miyata, Naoki]
通讯作者: Miyata, Naoki
DOI: 10.1016/j.cub.2012.04.013
发表时间: 2012-06-05
期刊: CURRENT BIOLOGY
影响因子: 9.2
作者: [Higashi, Torahiko L., Ikeda, Megumi, Takahashi, Tatsuro S.]
通讯作者: Takahashi, Tatsuro S.
Analysis of transcriptional regulation by Cohesin
Regulation of gene expression and chromosome structure by cohesin
  • 批准号:
    19710161
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.42万
  • 财政年份:
    2007
  • 负责人:
    BANDO Masashige
  • 依托单位:
海外基金