Molekulare Evolution von Reproduktionsgenen bei Drosophila

果蝇生殖基因的分子进化

• 批准号: 5417017
• 负责人: Professor Dr. John Parsch
• 金额: --
• 依托单位: Lehrstuhl für Evolutionsbiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2004
• 资助国家: 德国
• 起止时间: 2003-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5417017?language=en
• 关键词: Molekulare; Evolution; von; Reproduktionsgenen; bei

The goal of this project is to perform a general test of the faster male evolution hypothesis using recently available genomic resources from Drosophila melanogaster. The specific objectives are as follows: (1) Use the available genome sequence of D. melanogaster and data from EST and microarray experiments to identify genes with sex-specific or sex-enriched expression, (2) clone and sequence orthologs of these genes from other members of the D. melanogaster species subgroup, (3) determine the rate of molecular evolution of these genes based on the ratio of nonsynonymous/synonymous substitution rates among species and compare these rates among genes with male-, female- and non-biased expression, (4) test for the possible role of positive selection in the evolution of reproductive genes using recently developed statistical methods on both inter- and intraspecific DNA sequence data.

这个项目的目标是利用最近获得的黑腹果蝇基因组资源对更快的雄性进化假说进行一般性检验。具体目标如下：（1）利用已获得的D.（2）克隆和测序了来自黑腹果蝇其他成员的性别特异表达基因和性别富集表达基因;（3）根据物种间非同义/同义替换率的比值确定这些基因的分子进化速率，并比较雄性、雌性和非偏向表达基因的这些速率;（4）利用最近发展起来的统计学方法对种间和种内DNA序列数据进行检验，以检验正选择在生殖基因进化中的可能作用。