Evolution of Drosophila genes with sex-biased expression

具有性别偏向表达的果蝇基因的进化

• 批准号: 44172277
• 负责人: Professor Dr. John Parsch
• 金额: --
• 依托单位: Institut für Experimentelle Medizin (IEM)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/44172277?language=en
• 关键词: Evolution; Drosophila; genes; sex; biased

A common pattern that has emerged from genomic studies of Drosophila and other taxa is that male-biased genes (i.e., genes expressed predominantly or exclusively in males) evolve rapidly in comparison to female- and nonsex-biased genes. This pattern is thought to be a result of increased adaptive evolution in malebiased genes due to positive (or sexual) selection. However, it could also be explained by relaxed selective constraint. To distinguish between these possibilities and identify genes that have undergone recent adaptive evolution, we propose several population genetic and functional genomic analyses, including: (1) comparing rates of nonsynonymous/synonymous polymorphism and divergence in sex-biased genes, (2) comparing evolutionary patterns of X-linked vs. autosomal sex-biased genes, (3) performing microarray experiments to identify sex-biased genes in Drosophila species other than the well-characterized D. melanogaster, (4) functional analysis of putative adaptively-evolving male-biased genes, and (5) population genetic analysis of sex-biased genes in the highly-subdivided species, D. ananassae.

从果蝇和其他分类群的基因组研究中出现的一个共同模式是雄性偏向基因（即，主要或专门在男性中表达的基因）与女性和非性别偏向基因相比进化迅速。这种模式被认为是由于积极（或性）选择导致男性偏向基因的适应性进化增加的结果。然而，这也可以用放松的选择性约束来解释。为了区分这些可能性并识别最近经历适应性进化的基因，我们提出了几种群体遗传和功能基因组分析，包括：（1）比较性别偏向基因中非同义/同义多态性和分歧的比率，（2）比较X连锁与常染色体性别偏向基因的进化模式，（3）利用基因芯片技术，在果蝇中发现除D.（4）推测的适应性进化的雄性偏向基因的功能分析;（5）高度细分的种--黑腹果蝇（D. melanogaster）性别偏向基因的群体遗传分析。ananassae。