Rapid evolution of gene regulation

基因调控的快速进化

• 批准号: 274388701
• 负责人: Professor Dr. John Parsch
• 金额: --
• 依托单位: Department Biologie II (aufgelöst)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/274388701?language=en
• 关键词: Rapid; evolution; gene; regulation

Alterations in environmental conditions can lead to rapid, adaptive changes in gene expression. This project aims to understand cis-regulatory evolution in natural populations of the fruit fly Drosophila melanogaster. Using high-throughput RNA sequencing (RNA-seq) and reporter gene experiments, we will identify genetic variants that influence gene expression. Furthermore, we will determine the magnitude of their effect on gene expression and investigate their population dynamics.

环境条件的改变可以导致基因表达的快速适应性变化。本计画旨在了解黑腹果蝇自然族群的顺式调控演化。使用高通量RNA测序（RNA-seq）和报告基因实验，我们将确定影响基因表达的遗传变异。此外，我们将确定它们对基因表达的影响程度，并研究它们的种群动态。