Coordination of the French/German collaborative research group "Complex Fluids: From 3 to 2 Dimensions"

法国/德国合作研究小组“复杂流体：从3维到2维”的协调

• 批准号: 5418337
• 负责人: Professor Dr. Helmuth Möhwald (†)
• 金额: --
• 依托单位: Max-Planck-Institut für Kolloid- und Grenzflächenforschung
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2003
• 资助国家: 德国
• 起止时间: 2002-12-31 至 2008-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5418337?language=en
• 关键词: Coordination; French; German; collaborative; research

The interaction of phospholipids with polyelectrolytes and glycosidic polymers, both of biological origin, shall be investigated for layered systems. For amphiphile monolayers structural studies which concern the lipid arrangement in monolayers is studied by X-ray diffraction and FTIR spectroscopy. The polymer arrangement shall be investigated by ellipsometry, X-ray and Neutron reflectivity. The coupling shall be studied by FTIR and NMR spectroscopy with vesicles and coated colloids. Lateral diffusion of lipids will be investigated by fluorescence recovery after photobleaching. NMR techniques will also be employed to investigate the swelling of films and the fraction of water in the film as well a between film and lipid head groups. Of special interest will be the relation between coupling and dynamics, so1/gel transitions of polyelectrolytes and glycosidic polymers and their importance for modulation or ligand binding. Altogether the project aims at understanding the relation between structure and dynamics in coupled lipid/polymer systems and its relevance for biophysics and -chemistry.

对于分层系统，应研究磷脂与生物来源的聚电解质和糖苷聚合物的相互作用。对于两亲分子单分子膜的结构研究，涉及单分子膜中的脂质排列，通过X射线衍射和FTIR光谱进行了研究。应通过椭圆偏振法、X射线和中子反射率研究聚合物排列。应使用囊泡和涂层胶体通过FTIR和NMR光谱研究偶联。脂质的侧向扩散将通过光漂白后的荧光恢复来研究。核磁共振技术也将被用来研究膜的溶胀和膜中水的分数以及膜和脂质头基之间的距离。特别感兴趣的是耦合和动力学之间的关系，聚电解质和糖苷聚合物的so 1/凝胶转变及其对调制或配体结合的重要性。总的来说，该项目旨在了解耦合脂质/聚合物系统的结构和动力学之间的关系及其与生物物理和化学的相关性。