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Tail-anchored membrane proteins: prediction, targeting, assembly and function.

Tail-anchored membrane proteins: prediction, targeting, assembly and function.
尾锚定膜蛋白:预测、靶向、组装和功能。
批准号:
DP0208783
负责人:
Prof Trevor Lithgow
金额:
$22.21万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2002
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2002-01-01 至 2006-12-31

项目摘要

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中文摘要
翻译
使用基于计算机的基因组序列数据搜索,我们现在有一个完整的列表中的尾部锚定膜蛋白的酵母酿酒酵母。这些包括一些必需的蛋白质,如SNARE和TOM蛋白质负责在所有生物体,包括人的细胞膜的建设。在搜索中发现的其他蛋白质序列,8个代表已知功能的蛋白质,而19个是新的。我们建议研究这19种新蛋白质的亚细胞定位,并解决它们如何靶向和插入细胞膜的问题。我们还将研究新发现的蛋白质的功能。
英文摘要
Using computer-based searches of genome sequence data, we now have a complete list of tail-anchored membrane proteins in the yeast Saccharomyces cerevisiae. These include a number of essential proteins, such as SNAREs and TOM proteins responsible for building cellular membranes in all organisms, including man. Of the additional protein sequences discovered in the search, 8 represent proteins of known function while 19 are novel. We propose to study the subcellular location of these 19 novel proteins, and solve how they are targeted to and inserted in membranes. We will also investigate the function of the newly-discovered proteins.
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Investigation of the molecular machinery enabling phage to enter bacteria.
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    DP220100338
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  • 资助金额:
    $41.27万
  • 财政年份:
    2022
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  • 项目类别:
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  • 财政年份:
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The molecular blue-print for a mitochondrial nanomachine
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  • 项目类别:
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