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Tail-anchored membrane proteins: prediction, targeting, assembly and function.

Tail-anchored membrane proteins: prediction, targeting, assembly and function.
尾锚定膜蛋白：预测、靶向、组装和功能。
批准号：
DP0208783
负责人：
Prof Trevor Lithgow
金额：
$22.21万
依托单位：
The University of Melbourne
依托单位国家：
澳大利亚
项目类别：
Discovery Projects
财政年份：
2002
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2002-01-01 至 2006-12-31
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/DP0208783
关键词：
Tailanchoredmembraneproteinsprediction

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英文摘要
Using computer-based searches of genome sequence data, we now have a complete list of tail-anchored membrane proteins in the yeast Saccharomyces cerevisiae. These include a number of essential proteins, such as SNAREs and TOM proteins responsible for building cellular membranes in all organisms, including man. Of the additional protein sequences discovered in the search, 8 represent proteins of known function while 19 are novel. We propose to study the subcellular location of these 19 novel proteins, and solve how they are targeted to and inserted in membranes. We will also investigate the function of the newly-discovered proteins.
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