Preparation of chiral metal-free Lewis acids and their application in asymmetric catalysis

该提案涉及合成中几乎未被探索的无金属路易斯酸领域的发展，从一开始就专注于不对称催化实例。无金属工艺对未来至关重要，因为金属在合成中的应用是一个巨大问题的来源，如高昂的价格、毒性、污染、废物处理和产品污染。所需的Lewis酸，例如共振稳定的碳正离子，只需几个步骤就可以很容易地制备出来，并且可以用廉价的原料大规模地制备，并且结构和电子特征可以很容易地改变。这些手性催化剂将被广泛应用于合成重要的不对称反应以制备对映体化合物。后者具有非同寻常的意义，特别是如果靶子被用作药物的话。通常，当一种对映体显示出预期的效果时，另一种则不起作用。在更糟糕的情况下，相反的对映体可能是有毒的或致畸的。对映体化合物在农用化学品、香料、香料和许多其他产品中也具有重要作用。

The proposal deals with the development of the nearly unexplored field of metal-free Lewis acids in synthesis, focusing already from the very beginning on asymmetric catalytic examples. Metal-free processes are of paramount importance for the future, since the application of metals in synthesis is a source of enormous problems such as high price, toxicity, pollution, waste treatment and product contamination. The desired Lewis acids, e. g. resonance stabilized carbocations, can be readily prepared in only a few steps and on a large scale from cheap starting materials and structural and electronic features can be easily modified. The chiral catalysts will be applied to a broad range of synthetic important asymmetric reactions to prepare enantiopure compounds. The latter are of extraordinary significance, especially if the target is used as a drug. Often, while one enantiomer shows the desired effect, the other does not. In worse cases, the opposite enantiomer can be toxic or teratogenic. Enantiopure compounds are also of importance in agrochemicals, flavors, fragrances and many other products.