Preparation of chiral metal-free Lewis acids and their application in asymmetric catalysis

手性无金属路易斯酸的制备及其在不对称催化中的应用

• 批准号: 5418797
• 负责人: Professor Dr. René Wilhelm
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2004
• 资助国家: 德国
• 起止时间: 2003-12-31 至 2005-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5418797?language=en
• 关键词: Preparation; chiral; metal; free; Lewis

The proposal deals with the development of the nearly unexplored field of metal-free Lewis acids in synthesis, focusing already from the very beginning on asymmetric catalytic examples. Metal-free processes are of paramount importance for the future, since the application of metals in synthesis is a source of enormous problems such as high price, toxicity, pollution, waste treatment and product contamination. The desired Lewis acids, e. g. resonance stabilized carbocations, can be readily prepared in only a few steps and on a large scale from cheap starting materials and structural and electronic features can be easily modified. The chiral catalysts will be applied to a broad range of synthetic important asymmetric reactions to prepare enantiopure compounds. The latter are of extraordinary significance, especially if the target is used as a drug. Often, while one enantiomer shows the desired effect, the other does not. In worse cases, the opposite enantiomer can be toxic or teratogenic. Enantiopure compounds are also of importance in agrochemicals, flavors, fragrances and many other products.

该提案涉及合成中几乎未开发的无金属路易斯酸领域的发展，从一开始就关注不对称催化示例。无金属工艺对于未来至关重要，因为金属在合成中的应用会带来高价格、毒性、污染、废物处理和产品污染等巨大问题。所需的路易斯酸，例如。 g。共振稳定的碳正离子只需几个步骤即可轻松地用廉价的起始材料大规模地制备，并且可以轻松地修改结构和电子特征。手性催化剂将应用于广泛的合成重要不对称反应以制备对映体纯化合物。后者具有非凡的意义，特别是如果目标被用作药物。通常，虽然一种对映体显示出所需的效果，但另一种却没有。在更糟糕的情况下，相反的对映体可能有毒或致畸。对映体纯化合物在农用化学品、香料、香料和许多其他产品中也很重要。