Development of new therapeutic approach for multiple myeloma targeted against biological properties of bone marrow microenvironment

针对骨髓微环境的生物学特性开发多发性骨髓瘤新治疗方法

• 批准号: 24591409
• 负责人: KIZAKI Masahiro
• 金额: $ 3.49万
• 依托单位: Saitama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591409/
• 关键词: 多発性骨髄腫; 分子標的療法; 骨髄微小環境; 細胞死; NF-κB; 幹細胞; JAK/STAT; 前駆細胞; Wnt/β-カテニン

项目成果

TriptolideによるMcl-1抑制を介した多発性骨髄腫に対する抗腫瘍効果の解析

雷公藤甲素抑制Mcl-1介导的抗多发性骨髓瘤作用分析

• 发表时间: 2014
• 作者: 佐川森彦;富川武樹;得平道英;木崎昌弘
• 通讯作者: 木崎昌弘

TM-233, a novel analog of 1'-acetoxychavicol acetate, induces cell death in myeloma cells by inhibiting both JAK/STAT and proteasome activities.

• DOI: 10.1111/cas.12616
• 发表时间: 2015-04
• 期刊: Cancer science
• 影响因子: 5.7
• 作者: Sagawa M;Tabayashi T;Kimura Y;Tomikawa T;Nemoto-Anan T;Watanabe R;Tokuhira M;Ri M;Hashimoto Y;Iida S;Kizaki M
• 通讯作者: Kizaki M

Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway.

• DOI: 10.3892/ijo.2014.2652
• 发表时间: 2014-12
• 期刊: International journal of oncology
• 影响因子: 5.2
• 作者: Sadahira K;Sagawa M;Nakazato T;Uchida H;Ikeda Y;Okamoto S;Nakajima H;Kizaki M
• 通讯作者: Kizaki M

Shikonin, a naphthoquinone compound, rapidly induces cell death of human myeloma cells via production of reactive oxygen species

• 发表时间: 2014
• 作者: Takahiro Kimura;T. Nakazato;M. Kizaki

Targeting Wnt/β-catenin signaling pathway in multiple myeloma: A possible new therapeutic approach to overcome bortezomib-resistance

多发性骨髓瘤中靶向 Wnt/β-catenin 信号通路：克服硼替佐米耐药性的可能新治疗方法

• 发表时间: 2014
• 作者: Tabayashi T;Takahashi T;Kimura Y;Tomikawa T;Sagawa M;Nemoto T;Watanabe R;Tokuhira M;Mori S;Kizaki M
• 通讯作者: Kizaki M