The efficacy of renin-angiotensin system blockade for upper tract urothelial carcinoma

肾素-血管紧张素系统阻断治疗上尿路尿路上皮癌的疗效

• 批准号: 24791671
• 负责人: TANAKA Nobuyuki
• 金额: $ 2.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791671/
• 关键词: 尿路上皮癌; 血管新生; レニンアンギオテンシン; レニン・アンギオテンシン; ARB

Using a multi-institutional and retrospective cohort of patients with upper tract urothelial carcinoma (UTUC) in Japan, we found that the absence of renin-angiotensin system (RAS) inhibitors was significantly associated with disease recurrence following radical nephroureterectomy independent of other clinicopathological parameter, suggesting RAS inhibition might be effective to prevent subsequent relapsing in UTUC. Moreover, immunohistochemical analysis in surgical specimens revealed that the microvessel density in tumors was significantly associated with oncological outcome in UTUC patients, suggesting the importance of its upper modulator of RAS regulation in UTUC.

通过对日本上尿路上皮癌（UTUC）患者的多机构回顾性队列研究，我们发现肾素-血管紧张素系统（RAS）抑制剂的缺乏与根治性肾输尿管切除术后的疾病复发显著相关，而不受其他临床病理参数的影响，这表明RAS抑制可能有效预防UTUC的复发。此外，手术标本的免疫组化分析显示，肿瘤微血管密度与UTUC患者的肿瘤预后显著相关，提示其上调节因子RAS在UTUC中的重要作用。

项目成果

Predictive value of positive urine cytology for prognosis in patients with upper tract urothelial carcinoma following radical nephroureterectomy

尿细胞学阳性对上尿路尿路上皮癌根治性肾输尿管切除术后患者预后的预测价值

• 发表时间: 2013
• 作者: Tanaka N;Kikuchi E;Miyazaki Y;et al
• 通讯作者: et al

Prognostic Value of Renin-Angiotensin System Blockade in Non-muscle-invasive Bladder Cancer

• DOI: 10.1245/s10434-012-2568-z
• 发表时间: 2012-11-01
• 期刊: ANNALS OF SURGICAL ONCOLOGY
• 影响因子: 3.7
• 作者: Yuge, Kazuyuki;Miyajima, Akira;Oya, Mototsugu
• 通讯作者: Oya, Mototsugu

慶應義塾大学医学部 泌尿器科学教室

庆应义塾大学医学院泌尿外科

The Distinct Association Between Primary Tumor Location and the Patterns of Metastatic Spread Following Radical Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma

上尿路尿路上皮癌患者原发肿瘤位置与根治性肾输尿管切除术后转移扩散模式之间的明显关联

• 发表时间: 2013
• 作者: Tanaka N;Kikuchi E;Kanao K;et al
• 通讯作者: et al

Characteristics and Outcome in Metastatic Upper Tract Urothelial Carcinoma Following Radical Nephroureterectomy : The Multi-Institutional Experience

根治性肾输尿管切除术后转移性上尿路尿路上皮癌的特征和结果：多机构经验

• 发表时间: 2013
• 作者: Tanaka N;Kikuchi E;Shirotake S;et al
• 通讯作者: et al