The efficacy of renin-angiotensin system blockade for upper tract urothelial carcinoma
The efficacy of renin-angiotensin system blockade for upper tract urothelial carcinoma
批准号:
24791671
负责人:
TANAKA Nobuyuki
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
Using a multi-institutional and retrospective cohort of patients with upper tract urothelial carcinoma (UTUC) in Japan, we found that the absence of renin-angiotensin system (RAS) inhibitors was significantly associated with disease recurrence following radical nephroureterectomy independent of other clinicopathological parameter, suggesting RAS inhibition might be effective to prevent subsequent relapsing in UTUC. Moreover, immunohistochemical analysis in surgical specimens revealed that the microvessel density in tumors was significantly associated with oncological outcome in UTUC patients, suggesting the importance of its upper modulator of RAS regulation in UTUC.
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Predictive value of positive urine cytology for prognosis in patients with upper tract urothelial carcinoma following radical nephroureterectomy
尿细胞学阳性对上尿路尿路上皮癌根治性肾输尿管切除术后患者预后的预测价值
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Tanaka N, Kikuchi E, Miyazaki Y, et al]
通讯作者:
et al
DOI:
10.1245/s10434-012-2568-z
发表时间:
2012-11-01
期刊:
ANNALS OF SURGICAL ONCOLOGY
影响因子:
3.7
作者:
[Yuge, Kazuyuki, Miyajima, Akira, Oya, Mototsugu]
通讯作者:
Oya, Mototsugu
慶應義塾大学医学部 泌尿器科学教室
庆应义塾大学医学院泌尿外科
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
The Distinct Association Between Primary Tumor Location and the Patterns of Metastatic Spread Following Radical Nephroureterectomy in Patients with Upper Tract Urothelial Carcinoma
上尿路尿路上皮癌患者原发肿瘤位置与根治性肾输尿管切除术后转移扩散模式之间的明显关联
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Tanaka N, Kikuchi E, Kanao K, et al]
通讯作者:
et al
Characteristics and Outcome in Metastatic Upper Tract Urothelial Carcinoma Following Radical Nephroureterectomy : The Multi-Institutional Experience
根治性肾输尿管切除术后转移性上尿路尿路上皮癌的特征和结果:多机构经验
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Tanaka N, Kikuchi E, Shirotake S, et al]
通讯作者:
et al
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