Molecular biological Study of Muscle strengthening-enhancement for transcription by rehabilitation approach

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Aim of this study is to clarify the correlation between plasticity of central nervous system and various stimulation concerned as the main mechanism of functional recovery from dysfunction of central nervous system. The plasticity of central nervous system play a important role on the recovery of central nervous disease like stroke as well as heeling of lesion. Kaas reported that cortical reorganization made functional recovery after cortical injury on primate. Nudo et al. indicated the recovery of paralytic finger is obtained from repetitive exercise of the finger with enlargement of cortical finger motor area. Ikeda indicated cortical activity of transcription factor was enhanced immediate after spinal cord injury. However, there is no study about which stimulation is better on functional recovery. This study is to investigate the nature of stimulation which enhances the recovery on central nervous disease like stroke or spinal cord injury and to obtain mere recovery on clinical rehabilitation.We made cerebral infarction model using photosensitive die Rose-bengal and irradiate the 560nm green light on rat sensori-motor cortex and evaluated the functional recovery by Beam Walking test. Then we examined the expression of neurotrophic factor GDNF on the infarcted cortex. The expression of GDNF is significantly increased on the surrounding infarction at the period of functional recovery. Then we investigated the rehabilitative exercise effects on the hemiplegic infarcted rat. There is significant change between the exercise group and the non-exercise group. Additionally, complex exercise group recovered significantly earlier than simple exercise group. These findings suggested that appropriate exercise has more effects to functional recovery.