Translational research for craniofacial region using CNP

c型利钠肽（CNP）是一种通过软骨内成骨促进长骨和椎体发育的有效刺激物。在本研究中，我们研究了CNP对颅面骨形成的影响，颅面骨形成包括软骨内骨化和膜性骨化。对敲除CNP和转基因小鼠颅骨的形态计量学分析显示，CNP刺激沿颅骨长度的纵向生长，但不调节颅骨宽度。这些结果表明，CNP主要刺激颅面区域的软骨内成骨，对面中部骨骼形成至关重要。

C-type natriuretic peptide (CNP) is a potent stimulator of long bone and vertebra development via endochondral ossification. In the present study, we investigated the effects of CNP on craniofacial skeletogenesis, which consists of both endochondral and membranous ossifications. Morphometric analyses of crania from CNP knockout and transgenic mice revealed that CNP stimulates longitudinal growth along the cranium length, but does not regulate the cranium width. These results indicate that CNP primarily stimulates endochondral ossification in the craniofacial region and is crucial for midfacial skeletogenesis.