Study on a transcriptional coactivator-mediated regulation for plant virus intercellular movement

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In this study, the role of a tobacco transcriptional coactivator MBF1a (NtMBF1a), which can bind to the movement protein (MP) of Tomato mosaic virus (ToMV) in vitro, in virus cell-to-cell movement was investigated. Our results suggest that the transient over-expression of NtMBF1a has little effects on the initial and subsequent local spread of the virus, whereas the over-expressed NtMBF1a co-localizes with MP and may influence the localization of MP to plasmodesmata. Virus inoculation experiments using NtMBF1a-silenced transgenic plants suggest the possibility that virus infections may be reduced in those transgenic plants depending on the experimental conditions. These results provide novel findings of possible roles of NtMBF1a in virus infections.