Hepatoblasts might contribute to hepatic sinusoidal endothelial cells development

肝窦内皮细胞在肝脏发育、再生、血流调控和免疫反应中起重要作用。然而，肝窦内皮细胞的发育机制还不清楚。基于多篇文献，我们提出了肝细胞可能促进肝窦内皮细胞发育的假设。为了检验这一假设，我们产生了Hhex敲除小鼠作为无肝细胞肝小鼠。此后，使用Hhex敲除小鼠检查肝窦内皮细胞的发育和成肝细胞的作用。

Hepatic sinusoidal endothelial cells are an important roles for hepatic development and regeneration, control of blood flow in liver and immunoreaction. However, developmental mechanism of hepatic sinusoidal endothelial cells is not a little known. Based on several literatures, we formulated a hypothesis which hepatoblasts might contribute hepatic sinusoidal endothelial cells development. In order to examine the hypothesis, we generated Hhex knockout mice as hepatoblasts-less liver mice. Hereafter, development of hepatic sinusoidal endothelial cells and roles of hepatoblasts are examined using Hhex knockout mice.