Calcineurin B homologous protein (CHP3) regulates cardiomyocyte hypertrophy via inhibition of GSK3beta phosphorylation

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Calcineurin B homologous protein 3 (CHP3) is a 25-kDa calcium-binding protein mainly expressed in heart, but its function remains largely unknown. To understand the role of CHP3, we stably overexpressed CHP3 in fibroblast-derived cell line. When treated with insulin, there were significant decreases in phosphorylation level of GSK3beta in CHP3-overexpressed cells compared with that in control cells. Moreover, co-immunoprecipitation experiments demonstrated the interaction of CHP3 with GSK3beta. These results suggest that CHP3 serves as a novel regulatory factor for GSK3beta, which modulates cardiac hypertrophy.