Neural mechanism of age-related decline in circadian rhythmicity

与年龄相关的昼夜节律下降的神经机制

• 批准号: 24790238
• 负责人: NAKAMURA Takahiro
• 金额: $ 2.83万
• 依托单位: Teikyo Heisei University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790238/
• 关键词: 生体リズム; 加齢; 神経回路; 視床下部; 視交叉上核; 時計遺伝子; 電気生理

Aging is associated with changes in sleep amount, sleep quality, and specific sleep pathologies and disorders in humans. The dysfunction of the central circadian oscillator (SCN; suprachiasmatic nucleus of the hypothalamus in mammals) is recognized as one of the central causes of age-related sleep disturbances. However, it is still unclear how the SCN become senescent. In this study, we investigated to discover age-related molecules in the mouse SCN by means of DNA microarray. In the result, we found some molecules that the amount of expression increased or decreased in the aged SCN. If it is confirmed that these molecules contribute to the dysfunction of SCN, it would be a candidate for new treatment strategies for sleep disturbances in the aging population and would potentially improve the quality of life for aged individuals.

衰老与人类睡眠量、睡眠质量和特定睡眠病理和障碍的变化有关。中枢昼夜节律振荡器（SCN;哺乳动物下丘脑视交叉上核）的功能障碍被认为是与年龄相关的睡眠障碍的主要原因之一。然而，SCN是如何衰老的仍不清楚。本研究利用DNA微阵列技术探索小鼠SCN中与年龄相关的分子。结果发现，在衰老的SCN中，某些分子的表达量增加或减少。如果证实这些分子导致SCN功能障碍，它将成为老年人睡眠障碍新治疗策略的候选者，并可能改善老年人的生活质量。

项目成果

時間生物学

时间生物学

• 发表时间: 2012
• 作者: Nakagawa A.;et al.;寺田晃士;内匠透
• 通讯作者: 内匠透

Effects of age-related dopaminergic neuron loss in the substantia nigra on the circadian rhythms of locomotor activity in mice.

黑质中与年龄相关的多巴胺能神经元损失对小鼠运动活动昼夜节律的影响。

• DOI: 10.1016/j.neures.2012.09.005
• 发表时间: 2012
• 期刊: Neurosci. Res.
• 作者: Takasu NN;et al.;Tanaka M
• 通讯作者: Tanaka M

体内時計の光受容と反応性

生物钟的光感受和反应性

• 发表时间: 2014
• 作者: 中村 渉;中村 孝博
• 通讯作者: 中村 孝博

Role of the dopaminergic neurons present in the substantia nigra in age-related decline in circadian rhythmicity

黑质中多巴胺能神经元在年龄相关的昼夜节律下降中的作用

• 发表时间: 2012
• 作者: Takahiro J. Nakamura;Makoto Tanaka;Eriko Yamaguchi;Mami Takahashi;Kana Hashimura;Takao Shibata;Wataru Nakamura
• 通讯作者: Wataru Nakamura

TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages

• DOI: 10.4049/jimmunol.1300935
• 发表时间: 2014-05-01
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Goto, Yoshikuni;Ogawa, Kenji;Tsujimoto, Masafumi
• 通讯作者: Tsujimoto, Masafumi