Regulatory molecules for expression and function of endocytic receptor

一种内吞受体，megalin，在功能和结构上吸收肾上皮细胞中许多不同的蛋白质，并受接头蛋白的调节。在本研究中，我们鉴定了两个新的调节megalin内吞活性的接头蛋白，并揭示了这些接头蛋白的亚细胞定位和生理功能。我们的结果提示，一个调节巨蛋白从顶膜向早期内体转运的速率，另一个调节巨蛋白从上皮细胞内膜再循环到顶膜的循环。

An endocytic receptor, megalin, absorbs functionally and structurally distinct many proteins in the epithelial cells of the kidney with being regulated by adaptor proteins. In the present study, we identified two novel adaptor proteins to regulate the endocytic activity of megalin and revealed the subcellular localization and the physiological function of the adaptor proteins. Our results suggest that one regulates the rate of transportation of megalin from apical membrane to early endosome, and another regulates the recycling of megalin from recycling endosome to apical membrane in the epithelial cells.