The role of Keap1-Nrf2 system in obesity-induced pancreatic beta-cell dysfunctions

Keap 1-Nrf 2系统有助于保护免受包括氧化应激在内的环境应激。糖尿病是一种伴有严重并发症的代谢性疾病，保护胰腺β细胞功能障碍对于抑制糖尿病的发生和进展至关重要。激活Keap 1-Nrf 2系统强烈抑制肥胖诱导的糖尿病模型小鼠的胰腺β细胞功能障碍。nrf 2激活诱导肥胖诱导的糖尿病模型小鼠胰岛中的抗氧化基因。这些结果表明，Keap 1-Nrf 2系统可能是保护胰腺β细胞免受肥胖诱导的功能障碍的靶点。

The Keap1-Nrf2 system contributes to protect against environmental stress including oxidative stress. Diabetes mellitus is a metabolic disorder with severe complications, and the protection from pancreatic beta-cell dysfunction is important for the suppression of onset and progression of diabetes mellitus. Activation Keap1-Nrf2 system strongly suppressed pancreatic beta-cell dysfunction in obesity-induced diabetic model mice. Nrf2 activation induced antioxidant genes in isolated islets from obesity-induced diabetic model mice. These results indicate that the Keap1-Nrf2 system probably is a target for the protection of pancreatic beta-cells against obesity-induced dysfunctions.