The role of Keap1-Nrf2 system in obesity-induced pancreatic beta-cell dysfunctions

Keap1-Nrf2系统在肥胖引起的胰腺β细胞功能障碍中的作用

• 批准号: 24790306
• 负责人: URUNO Akira
• 金额: $ 2.83万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790306/
• 关键词: 膵β細胞; 糖尿病; 酸化ストレス; Keap1-Nrf2システム; Nrf2

The Keap1-Nrf2 system contributes to protect against environmental stress including oxidative stress. Diabetes mellitus is a metabolic disorder with severe complications, and the protection from pancreatic beta-cell dysfunction is important for the suppression of onset and progression of diabetes mellitus. Activation Keap1-Nrf2 system strongly suppressed pancreatic beta-cell dysfunction in obesity-induced diabetic model mice. Nrf2 activation induced antioxidant genes in isolated islets from obesity-induced diabetic model mice. These results indicate that the Keap1-Nrf2 system probably is a target for the protection of pancreatic beta-cells against obesity-induced dysfunctions.

Keap 1-Nrf 2系统有助于保护免受包括氧化应激在内的环境应激。糖尿病是一种伴有严重并发症的代谢性疾病，保护胰腺β细胞功能障碍对于抑制糖尿病的发生和进展至关重要。激活Keap 1-Nrf 2系统强烈抑制肥胖诱导的糖尿病模型小鼠的胰腺β细胞功能障碍。nrf 2激活诱导肥胖诱导的糖尿病模型小鼠胰岛中的抗氧化基因。这些结果表明，Keap 1-Nrf 2系统可能是保护胰腺β细胞免受肥胖诱导的功能障碍的靶点。

项目成果

Keap1-Nrf2システムによる惇8細胞保護作用

Keap1-Nrf2系统对Atun8细胞的保护作用

• 发表时间: 2013
• 期刊: 日本応用酵素協会誌
• 作者: Uruno A;Furusawa Y;Yagishita Y;Fukutomi T;Muramatsu H;Negishi T;Sugawara A;Kensler TW;Yamamoto M;5. 宇留野晃
• 通讯作者: 5. 宇留野晃

Telmisartan stimulates aldosterone synthase gene (CYP11B2) expression via the CaMK - mediated induction of NURR1

替米沙坦通过 CaMK 介导的 NURR1 诱导刺激醛固酮合酶基因 (CYP11B2) 的表达

• 发表时间: 2012
• 作者: Matsuda K;Uruno A;Saito-Ito T;Shimizu K;Kudo M;Satoh F;Yoshikawa T;Saito-Hakoda A;Ito S;Sugawara A
• 通讯作者: Sugawara A

Effects of PPARγ agonists against vascular and renal dysfunction

PPARγ激动剂对血管和肾功能障碍的影响

• DOI: 10.2174/1874467211205020248
• 发表时间: 2012
• 期刊: Curr Mol Pharmacol
• 影响因子: 2.7
• 作者: Sugawara A;Uruno A;Matsuda K;Saito-Ito T;Funato T;Saito-Hakoda A;Kudo M;Ito S.
• 通讯作者: Ito S.

Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma

• DOI: 10.1111/j.1349-7006.2012.02216.x
• 发表时间: 2012-04-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Inoue, Daisuke;Suzuki, Takashi;Yamamoto, Masayuki
• 通讯作者: Yamamoto, Masayuki

ARB affects nicotine-induced gene expression profile in human coronary artery endothelial cells.

ARB 影响人冠状动脉内皮细胞中尼古丁诱导的基因表达谱。

• DOI: 10.5494/wjh.v4.i1.7
• 发表时间: 2014
• 期刊: World Journal of Hypertension.
• 作者: Kudo M;Matsuda K;Sugawara K;Iki Y;Kogure N;Saito-Ito T;Shimizu K;Sato I; Yoshikawa T;Uruno A;Yokoyama A;Saito-Hakoda A;Ito S;Sugawara A.
• 通讯作者: Sugawara A.