The cerebral mechanism of pleasure of scratching and excessive scratcing

抓挠快感与过度抓挠的脑机制

• 批准号: 24790584
• 负责人: MOCHIZUKI Hideki
• 金额: $ 2.66万
• 依托单位: National Institute for Physiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790584/
• 关键词: 痒み; 掻破; 快感; 脳機能イメージング; itch; scratch; pleasure; fMRI

Excessive scratching is a significant problem for patients with chronic itch such as atopic dermatitis. One of causes of the excessive scratching is considered to be associated with pleasure induced by scratching. However, its cerebral mechanism was still unclear. The aim of this study is to investigate this mechanism in humans using functional brain imaging techniques. As a result, it was suggested that the reward system such as the midbrain and striatum, primary somatosensory cortex and insular cortex are associated with scratching-induced pleasantness. Moreover, it was observed that activity in motor-related regions such as the supplementary motor area, premotor cortex and cerebellum significantly increased while plaesurable feelings were evoked by scratching. The enhanced activity can explain why pleasure of scratching reinforces and motivates scratching behavior.

过度抓挠是患有慢性瘙痒如特应性皮炎的患者的重要问题。过度抓挠的原因之一被认为与抓挠引起的快感有关。但其脑机制尚不清楚。本研究的目的是使用功能性脑成像技术来研究人类的这种机制。结果表明，奖励系统，如中脑和纹状体，初级躯体感觉皮层和岛叶皮层与抓挠诱导的愉悦感有关。此外，据观察，在运动相关的区域，如辅助运动区，运动前皮质和小脑的活动显着增加，而愉快的感觉被抓挠引起。这种增强的活动可以解释为什么抓挠的快乐会加强和激励抓挠行为。

项目成果

なぜ痒いところを掻くと気持ちよくなるのか？ その脳内メカニズムを解明

为什么抓挠发痒的地方会让你感觉好一些？

Scratching-induced pleasantness

抓挠带来的愉悦感

• 发表时间: 2013
• 作者: Mochizuki H;Tanaka S;Morita T;Wasaka T;Sadato N;Kakigi R
• 通讯作者: Kakigi R

The cerebral representation of scratching-induced pleasantness

• DOI: 10.1152/jn.00374.2013
• 发表时间: 2014-02-01
• 期刊: JOURNAL OF NEUROPHYSIOLOGY
• 影响因子: 2.5
• 作者: Mochizuki, Hideki;Tanaka, Satoshi;Kakigi, Ryusuke
• 通讯作者: Kakigi, Ryusuke

掻破欲求に関連した磁場反応の計測

测量与刮擦欲望相关的磁场响应

• 发表时间: 2013
• 作者: Odo M;Koh K;Takada T;Yamashita A;Narita M;Kuzumaki N;Ikegami D;Sakai H;Iseki M;Inada E;Narita M.;望月秀紀,柿木隆介
• 通讯作者: 望月秀紀,柿木隆介

掻破欲求に関連した磁場反応の計測.

测量与刮擦欲望相关的磁场响应。

• 发表时间: 2013
• 作者: 望月秀紀;柿木隆介
• 通讯作者: 柿木隆介