Analysis of physical properties of actin filaments during differentiation of smooth muscle cells

肌动蛋白丝的动力学调节平滑肌细胞的分化。在本研究中，我研究了CRP 2，这是一个特定的转录辅因子平滑肌细胞相关基因，对肌动蛋白丝的结构和物理性质的影响。使用小角X射线散射分析证明了溶液中CRP 2的结构。CRP 2通过与肌动蛋白丝结合，增加肌动蛋白丝的直径和持久长度。此外，平滑肌细胞的机械性能增加CRP 2的过度表达。因此，我澄清了CRP 2是调节溶液中肌动蛋白丝的结构和物理性质的因子。

Dynamics of actin filaments regulate differentiation of smooth muscle cells. In this study, I examined the effects of CRP2, which is a specific transcription cofactor for smooth muscle cell related genes, on structure and physical property of actin filaments. The structure of CRP2 in solution was demonstrated using small angle X-ray scattering analysis. CRP2 increased the diameter and the persistent length of the actin filaments by binding with actin filaments. Furthermore, the mechanical properties of smooth muscle cells were increased by overexpression of CRP2. Therefore, I clarified that CRP2 was a factor regulating the structure and physical property of actin filaments in solution.