Elucidation of the adjustment mechanism with chemokines to fibrosis in tumor development and progression.

阐明趋化因子对肿瘤发生和进展中纤维化的调节机制。

• 批准号: 24700973
• 负责人: SASAKI Soichiro
• 金额: $ 2.91万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700973/
• 关键词: ケモカイン; 大腸がん; 線維化; HB-EGF

We investigated the cellular and molecular mechanism underlying chronic inflammation-associated carcinogenesis, by using mouse colon carcinogenesis caused by azoxymethane injection combined with repeated ingestion of dextran sodium sulphate solution.In this colon carcinogenesis process, colon tissues produced an inflammatory chemokine, CCL3, which induced fibroblasts to accumulate in and around tumor tissues and to produce a potent growth factor, heparin-binding epidermal growth factor-like growth factor (HB-EGF) in addition to the induction of inflammatory cell infiltration.These observations would indicate that CCL3 can contribute to chronic colitis-associated carcinogenesis by regulating not only inflammatory cell infiltration but also the accumulation and functions of fibroblasts, the cells that have crucial roles in tumor microenvironment. Thus, CCL3 can be a novel molecular target for inflammation-associated carcinogenesis.

我们通过使用小鼠结肠癌的结肠癌发生，研究了由甲氧基甲烷注射引起的小鼠结肠癌的发生，研究了慢性炎症相关的癌变的基础和分子机制，与硫代硫酸氢钠的反复摄入相结合。在这种结肠癌发生过程中，结肠组织对炎症性化合物产生了炎症，并构思于cloms clokine clo，clokine clo fib3组织并产生有效的生长因子，除了诱导炎症细胞浸润外，肝素结合表皮生长因子样生长因子（HB-EGF）。这些观察结果将CCL3表明CCL3可以表明慢性结肠炎与癌症相关的癌作用不仅可以通过炎症细胞渗透性来调节，而且还可以使炎症性侵蚀率累积累积，并有助于累积繁殖率和功能。在肿瘤微环境中。因此，CCL3可能是炎症相关癌变的新型分子靶标。

项目成果

CCL3-CCR5 axis regulates progression of fibrosis/carcinogenesis occurring as a result of chronic colitis in mice

CCL3-CCR5 轴调节小鼠慢性结肠炎导致的纤维化/癌变进展

• 发表时间: 2013
• 作者: 佐々木宗一郎;馬場智久;向田直史
• 通讯作者: 向田直史

Int. Cancer Targeted Drug Delivery; an Elusive Dream

国际。

• 发表时间: 2013
• 作者: Mukaida N;Sasaki S;Baba T
• 通讯作者: Baba T

A novel function of neutrophils via opioid peptides: maintenance of estrous cycle and regulation of pain

中性粒细胞通过阿片肽发挥新功能：维持动情周期和调节疼痛

• 发表时间: 2012
• 期刊: Seikagaku
• 作者: Kobayashi Yoshiro;Sasaki Soichiro
• 通讯作者: Sasaki Soichiro

CCL3-CCR5 axis regulates progression of fibrosis occurring as a result of chronic colitis in mice

CCL3-CCR5 轴调节小鼠慢性结肠炎导致的纤维化进展

• 发表时间: 2013
• 作者: Soichiro Sasaki;Tomohisa Baba;Naofumi Mukaida
• 通讯作者: Naofumi Mukaida

慢性炎症大腸炎モデルではCCL3/CCR5を介して線維化、癌化が進行する

在慢性炎症性结肠炎模型中，纤维化和癌变通过 CCL3/CCR5 进展

• 发表时间: 2013
• 作者: 佐々木宗一郎;馬場智久;向田直史
• 通讯作者: 向田直史