Flow behavior of soft objects like polymers, vesicles and cells in microchannels

微通道中聚合物、囊泡和细胞等软物体的流动行为

• 批准号: 5425082
• 负责人: Professor Dr. Gerhard Gompper
• 金额: --
• 依托单位: Theoretische Physik der Lebenden Materie (IBI-5/IAS-2)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2004
• 资助国家: 德国
• 起止时间: 2003-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5425082?language=en
• 关键词: Flow; behavior; soft; objects; like

The flow behavior of complex fluids consisting of soft objects like macromolecules (e.g. DNA), vesicles or blood cells will be studied in microchannels. We want to achieve a detailed understanding of the influence of the micrometer size geometry on the transport properties and the structures of the fluid. This comprises the change in conformations of the soft objects as well as a possible structure formation (e.g. aggregation). In addition the influence of soft boundaries on the fluid flow will be addressed. For this purpose we will perform computer simulations employing different techniques. To simulate the fluid flow we will exploit a particle-based mesoscale simulation technique (Multi-Particle-Collision dynamics) which accounts for hydrodynamic interactions. In addition, we will use molecular dynamics simulations and/or triangulated surface models to describe e.g. vesicles. We will start our investigations by considering single particles and then proceed to more complex systems with inter-particle interactions. Our simulations will provide microscopic insight into the interplay between confinement, boundary conditions, hydrodynamic interactions, and inter-particle interactions on the flow behavior of complex fluids.

由大分子（如DNA），囊泡或血细胞等软物体组成的复杂流体的流动行为将在微通道中进行研究。我们希望实现一个详细的了解的影响微米尺寸的几何形状上的传输特性和流体的结构。这包括柔软物体的构象变化以及可能的结构形成（例如聚集）。此外，软边界对流体流动的影响将得到解决。为此，我们将使用不同的技术进行计算机模拟。为了模拟流体流动，我们将利用基于粒子的中尺度模拟技术（多粒子碰撞动力学），该技术考虑了流体动力学相互作用。此外，我们将使用分子动力学模拟和/或三角形表面模型来描述例如囊泡。我们将从考虑单个粒子开始研究，然后继续研究具有粒子间相互作用的更复杂的系统。我们的模拟将提供微观洞察之间的相互作用的限制，边界条件，流体动力学相互作用，和粒子间的相互作用对复杂流体的流动行为。