Inverse vaccination for autoimmune diseases and therapy for their chronic progression by multi-functional antigen-specific regulatory cell governing multiple sclerosis

自身免疫性疾病的反向疫苗接种以及通过多功能抗原特异性调节细胞控制多发性硬化症慢性进展的治疗

• 批准号: 16K09706
• 负责人: Lin Youwei
• 金额: $ 3万
• 依托单位: National Center of Neurology and Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K09706/
• 关键词: 制御性Ｔ細胞; 抗原特異性; 脳炎惹起性ペプチド; 実験的自己免疫性脳脊髄炎; 多発性硬化症; 自己免疫ワクチン; 再発寛解維持; 慢性進行抑制; 抗原特異的制御性T細胞; MHC・ペプチド結合度; 寛解維持; 組織修復能; 寛解不全と進行; 安定型制御性T細胞; 組織修復; 寛解不全と慢性進行; 神経免疫疾患; 組織特異的自己免疫ワクチン; 慢性化制御

项目成果

Inverse vaccination for multiple sclerosis in control of the disease activity--superior dominant peptide restricts the reactivity to disease-associated antigens and promotes tissue-repair capacity by sequentially induction of stabilized antigen-specific h

多发性硬化症的反向疫苗接种控制疾病活动——优越的显性肽限制对疾病相关抗原的反应，并通过连续诱导稳定的抗原特异性 h 来促进组织修复能力

• 发表时间: 2018
• 作者: Samukawa M;Hirano M;Saigoh K;Kawai S;Hamada Y;Takahashi D;Nakamura Y;Kusunoki S.;Youwei Lin,;Youwei Lin
• 通讯作者: Youwei Lin

Manipulating the stability of antigen-specific Treg by enhancing the functional avidity of the superior dominant peptide via its flanking residues harnesses autoimmunity with restricting the reactivity to disease-related antigens and promoting tissue repa

通过侧翼残基增强优势肽的功能亲合力来操纵抗原特异性 Treg 的稳定性，利用自身免疫限制对疾病相关抗原的反应并促进组织修复

• 发表时间: 2018
• 作者: Youwei Lin;Takashi Yamamura
• 通讯作者: Takashi Yamamura

Inverse vaccination with superior dominant peptide may eradicate multiple sclerosis via sequential induction of stabilized hybrid regulatory T cells with antigen specificity and tissue repair capacity

使用优势肽进行反向疫苗接种可以通过连续诱导具有抗原特异性和组织修复能力的稳定混合调节性 T 细胞来根除多发性硬化症

• 发表时间: 2016
• 作者: Okazaki Masahiro;Suzuki Hidekazu;Takahashi Yuji;Ishiura Hiroyuki;Goto Jun;Hirano Makito;Saigoh Kazumasa;Nakamura Yusaku;Naruse Hiroya;Mitsui Jun;Tsuji Shoji;Kusunoki Susumu;Youwei Lin
• 通讯作者: Youwei Lin

SENSITIZATION OF SUPERIOR DOMINANT PEPTIDE MAY ERADICATE MULTIPLE SCLEROSIS THROUGHOUT BY SEQUENTIAL INDUCTION OF STABILIZED HYBRID REGULATORY T CELLS WITH DIVERSE ANTIGEN-SPECIFICITY AND TISSUE-REPAIR CAPACITY

高级显性肽的致敏可以通过连续诱导具有多种抗原特异性和组织修复能力的稳定化混合调节 T 细胞来根除多发性硬化症

• 发表时间: 2017
• 作者: Yoshikawa K;Kuwahara M;Saigoh K;Ishiura H;Yamagishi Y;Hamano Y;Samukawa M;Suzuki H;Hirano M;Mitsui Y;Tsuji S;Kusunoki S.;Youwei Lin
• 通讯作者: Youwei Lin

Antigen-specificity of superior dominant encephalitogenic peptide confers inductivity, stability, and hybrid signatures to CD69+CD103+ subset of Treg responsible for sustainable inhibition of CNS autoimmune diseases.

优越的显性致脑炎肽的抗原特异性赋予 Treg 的 CD69 CD103 子集诱导性、稳定性和混合特征，负责持续抑制 CNS 自身免疫性疾病。

• 发表时间: 2016
• 作者: Isono C;Hirano M;Sakamoto H;Ueno S;Kusunoki S;Nakamura Y.;Youwei Lin
• 通讯作者: Youwei Lin