Inverse vaccination for autoimmune diseases and therapy for their chronic progression by multi-functional antigen-specific regulatory cell governing multiple sclerosis
Inverse vaccination for autoimmune diseases and therapy for their chronic progression by multi-functional antigen-specific regulatory cell governing multiple sclerosis
批准号:
16K09706
负责人:
Lin Youwei
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2016
资助国家:
日本
项目状态:
已结题
起止时间:
2016-04-01 至 2019-03-31
中文摘要
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英文摘要
期刊论文(0)
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Inverse vaccination for multiple sclerosis in control of the disease activity--superior dominant peptide restricts the reactivity to disease-associated antigens and promotes tissue-repair capacity by sequentially induction of stabilized antigen-specific h
多发性硬化症的反向疫苗接种控制疾病活动——优越的显性肽限制对疾病相关抗原的反应,并通过连续诱导稳定的抗原特异性 h 来促进组织修复能力
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[Samukawa M, Hirano M, Saigoh K, Kawai S, Hamada Y, Takahashi D, Nakamura Y, Kusunoki S., Youwei Lin,, Youwei Lin]
通讯作者:
Youwei Lin
Manipulating the stability of antigen-specific Treg by enhancing the functional avidity of the superior dominant peptide via its flanking residues harnesses autoimmunity with restricting the reactivity to disease-related antigens and promoting tissue repa
通过侧翼残基增强优势肽的功能亲合力来操纵抗原特异性 Treg 的稳定性,利用自身免疫限制对疾病相关抗原的反应并促进组织修复
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[Youwei Lin, Takashi Yamamura]
通讯作者:
Takashi Yamamura
Inverse vaccination with superior dominant peptide may eradicate multiple sclerosis via sequential induction of stabilized hybrid regulatory T cells with antigen specificity and tissue repair capacity
使用优势肽进行反向疫苗接种可以通过连续诱导具有抗原特异性和组织修复能力的稳定混合调节性 T 细胞来根除多发性硬化症
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Okazaki Masahiro, Suzuki Hidekazu, Takahashi Yuji, Ishiura Hiroyuki, Goto Jun, Hirano Makito, Saigoh Kazumasa, Nakamura Yusaku, Naruse Hiroya, Mitsui Jun, Tsuji Shoji, Kusunoki Susumu, Youwei Lin]
通讯作者:
Youwei Lin
SENSITIZATION OF SUPERIOR DOMINANT PEPTIDE MAY ERADICATE MULTIPLE SCLEROSIS THROUGHOUT BY SEQUENTIAL INDUCTION OF STABILIZED HYBRID REGULATORY T CELLS WITH DIVERSE ANTIGEN-SPECIFICITY AND TISSUE-REPAIR CAPACITY
高级显性肽的致敏可以通过连续诱导具有多种抗原特异性和组织修复能力的稳定化混合调节 T 细胞来根除多发性硬化症
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[Yoshikawa K, Kuwahara M, Saigoh K, Ishiura H, Yamagishi Y, Hamano Y, Samukawa M, Suzuki H, Hirano M, Mitsui Y, Tsuji S, Kusunoki S., Youwei Lin]
通讯作者:
Youwei Lin
Antigen-specificity of superior dominant encephalitogenic peptide confers inductivity, stability, and hybrid signatures to CD69+CD103+ subset of Treg responsible for sustainable inhibition of CNS autoimmune diseases.
优越的显性致脑炎肽的抗原特异性赋予 Treg 的 CD69 CD103 子集诱导性、稳定性和混合特征,负责持续抑制 CNS 自身免疫性疾病。
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Isono C, Hirano M, Sakamoto H, Ueno S, Kusunoki S, Nakamura Y., Youwei Lin]
通讯作者:
Youwei Lin
共 10 条
induction of multi-functional regulatory T cell involved in maintenance of multiple sclerosis : application for vaccination of autoimmune diseases
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批准号:25461301
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2013
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负责人:Lin Youwei
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依托单位:
海外基金