Untersuchung des hippokampo-neokortikalen Dialogs im deklarativen Gedächtnis mittels funktioneller Magnetresonanztomographie (fMRT)

使用功能磁共振成像 (fMRI) 研究陈述性记忆中的海马-新皮质对话

• 批准号: 5449360
• 负责人: Professor Dr. Steffen Gais
• 金额: --
• 依托单位: Centre de Recherches du Cyclotron (GIGA-CRC)
• 依托单位国家: 德国
• 项目类别: Emmy Noether International Fellowships
• 财政年份: 2005
• 资助国家: 德国
• 起止时间: 2004-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5449360?language=en
• 关键词: Untersuchung; des; hippokampo; neokortikalen; Dialogs

Memory for facts and events, i.e. declarative memory, relies mainly on two brain structures: the hippocampus and the neocortex. Numerous studies have shown that acquisition and retrieval of new declarative memories depends on the hippocainpus. After some time, however, the memory trace becomes independent of it, indicating some kind of information transfer. Recently, the irnportance of sleep for this transfer of the memory trace has been discussed extensively. Especially slow-wave sleep is thought to drive this information transfer by reactivation of those neuronal networks that were active during learning. The experiments described here are aimed at finding correlates of this hippocampal-neocortical dialogue in human brain activity. The studies in phase I look at changes in hippocampal and neocortical activity during word list recall after sleep as compared to recall after periods of wakefulness. In addition, the dynamics of the hippocampal-neocortical information transfer will be modified experimentally by pharmacological manipulation of cholinergic neurotransmission. Activity will be recorded by means of fMRI and electroencephalography (EEG) recording. In phase II, brain activity during sleep will also be recorded to provide direct evidence for the model of a hippocampal-neocortical dialogue in humans.

对事实和事件的记忆，即陈述性记忆，主要依赖于两个大脑结构：海马体和新皮质。大量研究表明，新陈述性记忆的获取和检索取决于海马体。然而，一段时间后，记忆痕迹变得独立于它，表明某种信息传输。最近，睡眠对于记忆痕迹转移的重要性已被广泛讨论。特别是慢波睡眠被认为可以通过重新激活学习过程中活跃的神经元网络来驱动这种信息传递。这里描述的实验旨在寻找人类大脑活动中海马-新皮质对话的相关性。第一阶段的研究着眼于睡眠后单词列表回忆期间海马和新皮质活动的变化，并与清醒期后回忆进行比较。此外，海马-新皮质信息传递的动力学将通过胆碱能神经传递的药理学操作进行实验性修改。活动将通过功能磁共振成像和脑电图（EEG）记录来记录。在第二阶段，睡眠期间的大脑活动也将被记录下来，为人类海马-新皮质对话模型提供直接证据。