Untersuchung des hippokampo-neokortikalen Dialogs im deklarativen Gedächtnis mittels funktioneller Magnetresonanztomographie (fMRT)

对事实和事件的记忆，即陈述性记忆，主要依赖于两个大脑结构：海马体和新皮层。大量研究表明，新陈述性记忆的获得和提取依赖于大脑皮层。然而，一段时间后，记忆痕迹变得独立于它，表明某种信息传递。最近，睡眠对于记忆痕迹转移的重要性已经被广泛讨论。特别是慢波睡眠被认为是通过重新激活那些在学习过程中活跃的神经网络来驱动这种信息传递。这里描述的实验旨在寻找人类大脑活动中大脑皮层-新皮层对话的相关性。第一阶段的研究观察了睡眠后与清醒后回忆单词列表时海马和新皮层活动的变化。此外，海马-新皮层信息传递的动力学将通过胆碱能神经传递的药理学操作进行实验性修改。活动将通过fMRI和脑电描记术（EEG）记录的方式进行记录。在第二阶段，睡眠期间的大脑活动也将被记录下来，为人类大脑皮层-新皮层对话模型提供直接证据。

Memory for facts and events, i.e. declarative memory, relies mainly on two brain structures: the hippocampus and the neocortex. Numerous studies have shown that acquisition and retrieval of new declarative memories depends on the hippocainpus. After some time, however, the memory trace becomes independent of it, indicating some kind of information transfer. Recently, the irnportance of sleep for this transfer of the memory trace has been discussed extensively. Especially slow-wave sleep is thought to drive this information transfer by reactivation of those neuronal networks that were active during learning. The experiments described here are aimed at finding correlates of this hippocampal-neocortical dialogue in human brain activity. The studies in phase I look at changes in hippocampal and neocortical activity during word list recall after sleep as compared to recall after periods of wakefulness. In addition, the dynamics of the hippocampal-neocortical information transfer will be modified experimentally by pharmacological manipulation of cholinergic neurotransmission. Activity will be recorded by means of fMRI and electroencephalography (EEG) recording. In phase II, brain activity during sleep will also be recorded to provide direct evidence for the model of a hippocampal-neocortical dialogue in humans.