Reactivation in cortical and subcortical systems during consolidation of declarative memory - investigations in wakefulness and sleep

陈述性记忆巩固过程中皮质和皮质下系统的重新激活——觉醒和睡眠的研究

• 批准号: 65348950
• 负责人: Professor Dr. Steffen Gais
• 金额: --
• 依托单位: Institut für Medizinische Psychologie und Verhaltensneurobiologie
• 依托单位国家: 德国
• 项目类别: Independent Junior Research Groups
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/65348950?language=en
• 关键词: Reactivation; cortical; subcortical; systems; during

After encoding, new memory traces are initially fragile and have to undergo a process of consolidation. These processes can occur at the synaptic level as well as on a systems level. Sleep has been shown to play an important role for several types of memory. One of the most influential theories states that during sleep, new memory traces are reactivated repeatedly and thus strengthened, reprocessed and transferred between different storage locations. Starting from this hypothesis, the present project aims to find brain mechanisms which underlie memory consolidation in human declarative memory. Based on previous studies, special attention will be given to a number of coordinated events occurring during sleep: the sleep slow oscillation, sleep spindles, hippocampal and locus coeruleus (LC) activity. Using a new task that allows to study the effect of sleep on memory more efficiently, questions of the influence of interference intervening between learning and recall will be addressed. EEG studies are planned to find signs of memory reactivation in ongoing brain activity during sleep after periods of intensive learning. Combined EEG/fMRI will be used to test current hypothesis of memory transfer between different brain regions during sleep. By means of pharmacological manipulation of the noradrenergic system and concurrent functional magnetic resonance imaging (fMRI), the contribution of the LC to memory consolidation will be investigated. Additionally, the impact of medications reducing noradrenergic activity on long‐term memory function will be examined.

编码后，新的记忆痕迹最初是脆弱的，必须经历一个巩固的过程。这些过程可以发生在突触水平上，也可以发生在系统水平上。睡眠已被证明对几种类型的记忆起着重要作用。最有影响力的理论之一认为，在睡眠过程中，新的记忆痕迹会被反复激活，从而加强、重新处理并在不同的存储位置之间转移。从这一假设出发，本项目旨在发现人类陈述性记忆中巩固记忆的大脑机制。在以往研究的基础上，将特别关注睡眠中发生的一些协调事件：睡眠慢振荡、睡眠纺锤体、海马区和蓝斑(LC)活动。使用一项新的任务，可以更有效地研究睡眠对记忆的影响，将解决干扰在学习和回忆之间的影响的问题。EEG研究计划在经过一段时间的密集学习后，在睡眠中发现正在进行的大脑活动中记忆重新激活的迹象。结合EEG/fMRI将被用来检验当前关于睡眠期间不同大脑区域之间记忆转移的假说。通过去甲肾上腺素能系统的药理学操作和同步功能磁共振成像(FMRI)，将研究LC对记忆巩固的贡献。此外，还将检查减少去甲肾上腺素能活动的药物对长期记忆功能的影响。

项目成果

Exploring the effect of sleep and reduced interference on different forms of declarative memory.

• DOI: 10.5665/sleep.4258
• 发表时间: 2014-12
• 期刊: Sleep
• 影响因子: 5.6
• 作者: M. Schönauer;Annedore Pawlizki;C. Köck;S. Gais

Sleep-mediated memory consolidation depends on the level of integration at encoding

• DOI: 10.1016/j.nlm.2016.11.019
• 发表时间: 2017-01-01
• 期刊: NEUROBIOLOGY OF LEARNING AND MEMORY
• 影响因子: 2.7
• 作者: Himmer, Lea;Mueller, Elias;Schoenauer, Monika
• 通讯作者: Schoenauer, Monika

Rapid and independent memory formation in the parietal cortex

• DOI: 10.1073/pnas.1605719113
• 发表时间: 2016-11-15
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Brodt, Svenja;Poehlchen, Dorothee;Schoenauer, Monika
• 通讯作者: Schoenauer, Monika