Examination of Caffeine Metabolism Changes and Parkinson's Disease Symptom Correlation Based on Metabolite-Related Gene Analysis

基于代谢相关基因分析检查咖啡因代谢变化与帕金森病症状的相关性

• 批准号: 17K07797
• 负责人: SUMIYOSHI KATSUHIKO
• 金额: $ 3万
• 依托单位: Tokiwa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K07797/
• 关键词: カフェイン; パーキンソン病; 代謝; カフェイン代謝; 神経科学

项目成果

Reply: <i>PSAP</i> variants in Parkinson’s disease: a large cohort study in Chinese mainland population

回复：帕金森病的<i>PSAP</i>变异：中国大陆人群的大型队列研究

• DOI: 10.1093/brain/awaa393
• 发表时间: 2021
• 期刊: Brain
• 影响因子: 14.5
• 作者: Oji Yutaka;Hatano Taku;Funayama Manabu;Hattori Nobutaka
• 通讯作者: Hattori Nobutaka

Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease.

• DOI: 10.1212/wnl.0000000000004888
• 发表时间: 2018-01-30
• 期刊: Neurology
• 影响因子: 9.9
• 作者: Fujimaki M;Saiki S;Li Y;Kaga N;Taka H;Hatano T;Ishikawa KI;Oji Y;Mori A;Okuzumi A;Koinuma T;Ueno SI;Imamichi Y;Ueno T;Miura Y;Funayama M;Hattori N
• 通讯作者: Hattori N

Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson's disease.

• DOI: 10.1038/s41598-017-06767-y
• 发表时间: 2017-08-04
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Saiki S;Hatano T;Fujimaki M;Ishikawa KI;Mori A;Oji Y;Okuzumi A;Fukuhara T;Koinuma T;Imamichi Y;Nagumo M;Furuya N;Nojiri S;Amo T;Yamashiro K;Hattori N
• 通讯作者: Hattori N

Shared Metabolic Profile of Caffeine in Parkinsonian Disorders

• DOI: 10.1002/mds.28068
• 发表时间: 2020-05
• 期刊: Movement Disorders
• 影响因子: 8.6
• 作者: H. Takeshige-Amano;S. Saiki;M. Fujimaki;S. Ueno;Yuanzhe Li;T. Hatano;K. Ishikawa;Y. Oji;A. Mori;A. Okuzumi;T. Tsunemi;K. Daida;Y. Ishiguro;Yoko Imamichi;Hisayoshi Nanmo;S. Nojiri;M. Funayama;N. Hattori

Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice.

• DOI: 10.1038/s41598-018-21325-w
• 发表时间: 2018-02-12
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Sato S;Uchihara T;Fukuda T;Noda S;Kondo H;Saiki S;Komatsu M;Uchiyama Y;Tanaka K;Hattori N
• 通讯作者: Hattori N