The alteration of the sphingolipid metabolism of anti-cancer drug resistant tumor cells and the overcome of these resistance by the phytochemicals

抗癌药物耐药肿瘤细胞鞘脂代谢的改变以及植物化学物质克服这些耐药性

• 批准号: 17K09025
• 负责人: MURATE Takashi
• 金额: $ 3万
• 依托单位: Chubu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09025/
• 关键词: tumor cell; anti cancer drug; resistance; paclitaxel; resveratrol; vaticanol C; sphingolipid; apoptosis; sphingolipid metabolism; anti-cancer drug; sphingosine kinase; GCS; Ph+ALL; imatinib resistance; BCL2 inhibitor; JNK inhibitor; synerg

项目成果

Modulation of the sphingolipid rheostat is involved in paclitaxel resistance of the human prostate cancer cell line PC3-PR

• DOI: 10.1016/j.bbrc.2017.03.084
• 发表时间: 2017-04-29
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Aoyama, Yuka;Sobue, Sayaka;Murate, Takashi
• 通讯作者: Murate, Takashi

Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells

• DOI: 10.1016/j.bbrc.2020.02.165
• 发表时间: 2020-05-14
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Inoue, Chisato;Sobue, Sayaka;Murate, Takahsi
• 通讯作者: Murate, Takahsi

Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes

• DOI: 10.18999/nagjms.82.2.261
• 发表时间: 2020-05-01
• 期刊: NAGOYA JOURNAL OF MEDICAL SCIENCE
• 影响因子: 0.9
• 作者: Inoue, Chisato;Sobue, Sayaka;Murate, Takashi
• 通讯作者: Murate, Takashi