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Parameter-based assessment of visual attention: functional neuroanatomy, timing and interference

基于参数的视觉注意力评估：功能神经解剖学、时序和干扰

基本信息

批准号：
5451557
负责人：
Professor Dr. Stephan A. Brandt
金额：
--
依托单位：
Klinik für Neurologie mit Experimenteller Neurologie (CCM)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2005
资助国家：
德国
起止时间：
2004-12-31 至 2014-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/5451557?language=en
关键词：
Parameter based assessment visual attention

项目摘要

Understanding the mechanisms of visuo-spatial attention is of particular importance both from the perspective of basic visual neuroscience and from the perspective of clinical neurology; as the allocation of attention in space is a prerequisite for the effective interaction with our visual environment. The aim of this proposal is to provide further evidences of top-down and bottomup process by combining behavioural measures, functional magnetic resonance imaging (fMRI) and the analysis of effective connectivity. Based on a series of pilot experiments several hypotheses will be tested, according to the basic assumption that the focus of attention can be split if targets are distributed across hemifields. In an event-related parametric design we will analyze the correlation between behavioural measures (reaction times and error rates) and the hemodynamic response of early visual and parietal cortical areas. Our approach has several advantages, which go beyond previous work in the field; i) it allows a separate analysis of the cueing period and the target selection period and their related activation within each of the retinotopic regions of interest (ROIs), ii) varying the saliency of targets will allow us to examine task difficulty effects and their impact on the cueing period and the target selection period, iii) the analysis of the attentional modulation of connectivity between multiple ROIs will allow quantification of contextual modifications of neural interactions within early visual areas as well as between early visual areas and areas in parietal and frontal cortex.

从基础视觉神经科学和临床神经学的角度来看，理解视觉空间注意的机制都是特别重要的;因为注意在空间中的分配是与我们的视觉环境有效互动的先决条件。本研究的目的是通过结合行为测量、功能性磁共振成像（fMRI）和有效连接分析，进一步提供自上而下和自下而上过程的证据。基于一系列的试点实验的几个假设将进行测试，根据的基本假设，即注意力的焦点可以分裂，如果目标分布在hemifields。在事件相关的参数设计中，我们将分析行为指标（反应时间和错误率）与早期视觉和顶叶皮层区域的血流动力学反应之间的相关性。我们的方法有几个优点，这超出了以前在该领域的工作; i）它允许单独分析提示期和目标选择期以及它们在每个视网膜定位感兴趣区域（ROI）内的相关激活，ii）改变目标的显著性将允许我们检查任务难度效应及其对提示期和目标选择期的影响，iii）对多个ROI之间的连接性的注意力调制的分析将允许量化早期视觉区域内以及早期视觉区域与顶叶和额叶皮层中的区域之间的神经交互的上下文修改。